PredictedSpeciesReactivity:Mouse,RatProductFormat:Liquid.100ulin10mMHEPES(pH7.5),150mMNaCl,100ugpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.Clonality:PolyclonalHost:RabbitApplication:WB,IHCAdditionalInformation:Packaging:100ulin10mMHEPES(pH7.5),150mMNaCl,100ugpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.ReconstitutionandStorage:Forlongtermstorage-20Cisrecommended.Stableat-20Cforatleast1year.GeneSymbol:SLC6A1NCBIGeneId:79212ProteinName:Sodium-andchloride-dependentGABAtransporter1SwissprotId:P23978ProteinAccession#:NP_077347.1DescriptionofTarget:Gamma-aminobutyricacid(GABA)istheprimaryinhibitoryneurotransmitterinthecentralnervoussystem,causingahyperpolarizationofthemembranethroughtheopeningofaCl-channelassociatedwiththeGABAAreceptor(GABAA-R)subtype.GABAplasmamembranetransporters(GATs)influencesynapticneurotransmissionbyhigh-affinityuptakeandreleaseofGABA.Todate,fourdistinctGABAtransportershavebeenidentified:GAT-1,GAT-2,GAT-3,andBGT-1.GAT-1,themostabundantofthetransporters,isfoundpredominantlyinneurons,butalsoinsomespecializedglia(Minellietal.,1995).GAT-1isthoughttoplayakeyroleinepileptogenesis(Zhaoetal.2003).MolecularWeight:~67kDaPurification:Preparedfromrabbitserumbyaffinitypurification.TissueTool:FindtissuesandcelllinessupportedbyDNAarrayanalysistoexpressSLC6A1.
RNASeq:FindtissuesandcelllinessupportedbyDNAarrayanalysistoexpressSLC6A1.
Immunogen:PeptidecorrespondingtoaminoacidresiduesfromtheC-terminalregionofratGAT-1.PredictedHomologyBasedonImmunogenSequence:Mouse;RatDatasheets/Manuals:PrintabledatasheetforOAPC00137Specificity:Specificforthe~67kGAT-1protein.Immunolabelingisblockedbythepeptideusedasantigen. 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
