Gene Symbol:SLC6A1NCBI Gene Id:79212Protein Name:Sodium- and chloride-dependent GABA transporter 1Swissprot Id:P23978Protein Accession #:NP_077347.1Description of Target:Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).Molecular Weight:~67kDaHost:RabbitClonality:PolyclonalPurification:Prepared from rabbit serum by affinity purification.Application:WB, IHCTissue Tool:Find tissues and cell lines supported by DNA array analysis to express SLC6A1. 
RNA Seq:Find tissues and cell lines supported by DNA array analysis to express SLC6A1. 
Immunogen:Peptide corresponding to amino acid residues from the C-terminal region of rat GAT-1.Predicted Species Reactivity:Mouse, RatPredicted Homology Based on Immunogen Sequence:Mouse; RatProduct Format:Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.Reconstitution and Storage:For long term storage -20C is recommended. Stable at -20C for at least 1 year.Datasheets/Manuals:Printable datasheet for OAPC00137Specificity:Specific for the ~67k GAT-1 protein. Immunolabeling is blocked by the peptide used as antigen. 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
