Gene Symbol:TFAMNCBI Gene Id:21780Protein Name:Transcription factor A, mitochondrialSwissprot Id:P40630Protein Accession #:NP_033386Nucleotide Accession #:NM_009360Replacement Item:This antibody may replace item sc-166965 from Santa Cruz Biotechnology.Description of Target:Mitochondrial Transcription Factor A (TFAM) is a key activator of mitochondrial (mt) DNA transcription as well as a participant in mitochondrial genome replication. mtDNA is highly susceptible to oxidative stress leading to mitochondrial dysfunction. Overexpression of TFAM has been implicated in the amelioration of age dependent impairment of brain functions through the prevention of oxidative stress and mitochondrial dysfunction in microglia (Hayashi et al., 2008). More recently, TFAM overexpression has been shown to potentially reduce oxidative stress in motor neurons and delay onset of amyotrophic lateral sclerosis (ALS) in ALS model mice (Morimoto et al., 2012).Molecular Weight:~24kDaHost:RabbitClonality:PolyclonalPurification:serumApplication:WBTissue Tool:Find tissues and cell lines supported by DNA array analysis to express TFAM. 
RNA Seq:Find tissues and cell lines supported by DNA array analysis to express TFAM. 
Immunogen:Native recombinant mouse TFAM protein with c-terminal 6-his tagPredicted Species Reactivity:Human, Mouse, RatPredicted Homology Based on Immunogen Sequence:Human; Mouse; RatProduct Format:Liquid. 100 ul neat serumReconstitution and Storage:Store at -20C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.Datasheets/Manuals:Printable datasheet for OAPC00069Specificity:Specific for the ~24 kDa TFAM protein. 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
