TestedSpeciesReactivity:HumanPredictedSpeciesReactivity:HumanProductFormat:Liquid.Purifiedantibodysuppliedin1xPBSbufferwith0.09%(w/v)sodiumazideand2%sucrose.Clonality:PolyclonalHost:RabbitApplication:WBReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.GeneSymbol:CHEK2OfficialGeneFullName:checkpointkinase2NCBIGeneId:11200ProteinName:Serine/threonine-proteinkinaseChk2SwissprotId:O96017-4ProteinAccession#:NP_001005735.1NucleotideAccession#:NM_001005735.1AliasSymbols:CDS1,CHK2,LFS2,RAD53,hCds1,HuCds1,PP1425DescriptionofTarget:InresponsetoDNAdamageandreplicationblocks,cellcycleprogressionishaltedthroughthecontrolofcriticalcellcycleregulators.Theproteinencodedbythisgeneisacellcyclecheckpointregulatorandputativetumorsuppressor.Itcontainsaforkhead-associatedproteininteractiondomainessentialforactivationinresponsetoDNAdamageandisrapidlyphosphorylatedinresponsetoreplicationblocksandDNAdamage.Whenactivated,theencodedproteinisknowntoinhibitCDC25Cphosphatase,preventingentryintomitosis,andhasbeenshowntostABIlizethetumorsuppressorproteinp53,leADIngtocellcyclearrestinG1.Inaddition,thisproteininteractswithandphosphorylatesBRCA1,allowingBRCA1torestoresurvivalafterDNAdamage.MutationsinthisgenehavebeenlinkedwithLi-Fraumenisyndrome,ahighlypenetrantfamilialcancerphenotypeusuallyassociatedwithinheritedmutationsinTP53.Also,mutationsinthisgenearethoughttoconferapredispositiontosarcomas,breastcancer,andbraintumors.ThisnuclearproteinisamemberoftheCDS1subfamilyofserine/threonineproteinkinases.Severaltranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene. ProteinSize(#AA):452MolecularWeight:50kDaPurification:AffinitypurifiedTissueTool:FindtissuesandcelllinessupportedbyDNAarrayanalysistoexpressCHEK2.
RNASeq:FindtissuesandcelllinessupportedbyRNA-seqanalysistoexpressCHEK2.
Immunogen:TheimmunogenisasyntheticpeptidedirectedtowardstheCterminalregionofhumanCHEK2PeptideSequence:Syntheticpeptidelocatedwithinthefollowingregion:MKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAConcentration:Batchdependentwithinrange:100ulat0.5-1mg/mlBlockingPeptide:Foranti-CHEK2(ARP86993_P050)antibodyisCatalog#AAP86993Datasheets/Manuals:Printabledatasheetforanti-CHEK2(ARP86993_P050)antibody 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
