Predicted Species Reactivity:Human, Mouse, RatProduct Format:Lyophilized from 5 mM ammonium bicarbonate. Adequate amount of material to conduct 10-mini Western Blots.Clonality:PolyclonalHost:RabbitApplication:WB, IHCAdditional Information:Packaging : 25 ug antibody vial; lyophilized from 5 mM ammonium bicarbonate. Adequate amount of material to conduct 10-mini Western Blots.Reconstitution and Storage:For long term storage -20C is recommended. Stable at -20C for at least 1 year. The antibody should be reconstitutedin 50 ul phosphate buffered saline (PBS: 137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use. Afterreconstitution the antibody should be aliquoted and stored at -20C.Gene Symbol:GRIN1NCBI Gene Id:24408Protein Name:Glutamate receptor ionotropic, NMDA 1Swissprot Id:P35439Protein Accession #:NP_001257531.1Description of Target:The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA Receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). There are a number of different splice variants of the NR1 subunit (Foldes et al., 1994; Zukin and Bennett, 1995). Differential splicing of three exons in the NR1 subunit generates up to eight NR1 subunit splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.Molecular Weight:~120kDaPurification:Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.Tissue Tool:Find tissues and cell lines supported by DNA array analysis to express GRIN1. 
RNA Seq:Find tissues and cell lines supported by DNA array analysis to express GRIN1. 
Immunogen:Peptide from the NR1 subunit, C2 splice variant insert of rat NMDA receptor.Predicted Homology Based on Immunogen Sequence:Human; Mouse; RatDatasheets/Manuals:Printable datasheet for OAPC00041Specificity:Specific for the ~120k NR1 subunit of the NMDA Receptor containing the C2 splice variant insert. Does not recognize the NR1 subunits of the NMDA receptor that do not contain the C2 insert. 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
