Kit Component:Toxoplasma gondii:1.Toxoplasma gondiiAntigen Grade II Catalog #: OPMA04845; 1 vial = 0.2ml2. Toxoplasma gondiiAntigen Grade III Catalog #: OPMA04846; 1 vial = 0.2mlRubella virus Antigen Grade IV:Catalog # OPMA04524; 1 vial = 0.2mlCMV IgM Concentrate Antigen:Catalog #: OPMA04847;1 vial = 0.2ml
HSV‐1 Antigen: Catalog #OPMA04527;1 vial = 0.4ml
HSV‐2 Antigen:Catalog #OPMA045216;1 vial = 0.4ml
HSV‐1 gG Antigen:Catalog #OPMA04777;1 vial = 0.2ml
HSV‐2 gG Antigen:Catalog #OPMA04778;1 vial = 0.2ml
Reconstitution and Storage:Ship in dry ice, Store at ≤‐65CDatasheets/Manuals:Printable datasheet/reference manual for TORCH Antigen Sample Kit (OKMA00002)OKMA00002Target Reference:Centers for Disease Control and Prevention (2013):Parasites ‐ Toxoplasmosis (Toxoplasma infection). Retrieved from : //www.cdc.gov/parasites/toxoplasmosis/disease.html Cytomegalovirus (CMV) and Congenital CMV Infection.Retrieved from: //www.cdc.gov/cmv/testing‐diagnosis.htmlNahmias, AJ, Walls KW, Stewart JA, et al. The ToRCH complex‐perinatal infections associated with toxoplasma and rubella, cytomegalo‐ and herpes simplex viruses. Pediatr Res. 1971;5:405‐406Introduction:TORCH is an acronym for a group of infections that can cause significant birth defects and even fetal death.Toxoplasmosis Other: syphilis, hepatitis B, Coxsackie virus, Epstein-Barr virus (EBV), human parvovirus, and varicella zoster Rubella Cytomegalovirus (CMV) Herpes simplex virus (HSV) Between 2‐3% of all congenital anomalies are attributed to perinatal infections, of which the TORCH agents are the most common cause of infection. The TORCH organisms typically are asymptomatic or cause only mild infections in the mother; however, there are much more serious consequences for infection to the fetus. In addition, TORCH infections pose a greater risk to the fetus and neonate if the mother is actively infected during pregnancy. Primary infections (newly acquired during pregnancy) are generally more damaging than secondary or reactivated infections. For example in the case of Rubella, infection to the mother during the first 12 weeks of gestation leads to congenital rubella syndrome in 80% of fetus and poor outcome; however, congenital infection during the second half of pregnancy has minimal risk to the fetus. For T. gondii., although the risk of maternal transmission is lowest in the first trimester, congenital disease is the most severe during this phase and often results in fetal death. CMV, which is the most common cause of congenital infectious disease, has a much higher rate of transmission (10% vs. 1%) for mothers with a primary infection compared to a reactivation.For most TORCH organisms, the initial screening test is based on detection of antibodies to the organism. Assays are commercially available for the detection of IgG antibodies, IgM antibodies, or both IgG and IgM antibodies. In most cases, IgG reactivity in the absence of IgM reactivity is indicative of a past infection, while IgM reactivity in the absence of IgG reactivity indicates a current infection. However, for toxoplasmosis and CMV infections, IgG avidity has recently been found to be useful for identifying primary infections. Since IgM antibodies can be produced following reactivation or re‐ infection in some individuals, a positive IgM is not necessarily indicative of a primary, active infection. In addition, it has been demonstrated that IgG antibody produced in the first few months following an initial infection has a lower avidity than IgG antibody produced several months or years later; consequently, low‐avidity antibody can be used to specifically identify high‐risk mothers with a primary infection. Overall to protect a fetus from TORCH infection, early diagnosis through first trimester screening is critical. Most TORCH infections are asymptomatic for the mother but can lead to serious birth defects or death for the fetus if left untreated. 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
