GeneSymbol:PCDH12NCBIGeneId:51294AliasSymbols:VECAD2,VE-cadherin-2ProteinName:Protocadherin-12DescriptionofTarget:Thisgenebelongstotheprotocadheringenefamily,asubfamilyofthecadherinsuperfamily.Theencodedproteinconsistsofanextracellulardomaincontaining6cadherinrepeats,atransmembranedomainandacytoplasmictailthatdiffersfromthoseoftheclassicalcadherins.Thegenelocalizestotheregiononchromosome5wheretheprotocadheringeneclustersreside.Theexonorganizationofthistranscriptissimilartothatofthegeneclustertranscripts,notablythefirstlargeexon,butnosignificantsequencehomologyexists.Thefunctionofthiscellularadhesionproteinisundeterminedbutmouseprotocadherin12doesnotbindcateninsandappearstohavenoaffectoncellmigrationorgrowth.SwissprotId:Q9NPG4ProteinAccession#:NP_057664NucleotideAccession#:BC042634TissueTool:FindtissuesandcelllinessupportedbyDNAarrayanalysistoexpressPCDH12.
RNASeq:FindtissuesandcelllinessupportedbyRNA-seqanalysistoexpressPCDH12.
我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物,这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌,哺乳动物细胞和昆虫细胞中表达,并作为整体裂解物提供。