Gene Symbol:CYP1A1NCBI Gene Id:1543Alias Symbols:AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DXProtein Name:Cytochrome P450 1A1Description of Target:This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Swissprot Id:P04798Protein Accession #:NP_000490Nucleotide Accession #:BC023019Tissue Tool:Find tissues and cell lines supported by DNA array analysis to express CYP1A1. RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express CYP1A1. 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物,这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌,哺乳动物细胞和昆虫细胞中表达,并作为整体裂解物提供。