Tested Species Reactivity:HumanPredicted Species Reactivity:Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, ZebrafishProduct Format:Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.Clonality:PolyclonalHost:RabbitApplication:WBReconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Replacement Item:This antibody may replace item sc-116480 from Santa Cruz Biotechnology.Immunogen:The immunogen is a synthetic peptide directed towards the middle region of human MTA2Purification:Affinity PurifiedPredicted Homology Based on Immunogen Sequence:Cow: 93%; Dog: 93%; Goat: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93%; Zebrafish: 79%Complete computational species homology data:Anti-MTA2 (ARP35743_P050)Peptide Sequence:Synthetic peptide located within the following region: WKKYGGLKTPTQLEGATRGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLConcentration:Batch dependent within range: 100 ul at 0.5 - 1 mg/mlBlocking Peptide:For anti-MTA2 (ARP35743_P050) antibody is Catalog # AAP35743 (Previous Catalog # AAPP06989)Datasheets/Manuals:Printable datasheet for anti-MTA2 (ARP35743_P050) antibodySample Type Confirmation:MTA2 is supported by BioGPS gene expression data to be expressed in 721_B
Target Reference:Olsen,J.V., (2006) Cell 127 (3), 635-648 Gene Symbol:MTA2Official Gene Full Name:Metastasis associated 1 family, member 2Alias Symbols:DKFZp686F2281, MTA1L1, PIDNCBI Gene Id:9219Protein Name:Metastasis-associated protein MTA2Description of Target:MTA2 has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling.This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.Swissprot Id:O94776Protein Accession #:NP_004730Nucleotide Accession #:NM_004739Protein Size (# AA):668Molecular Weight:75kDaTissue Tool:Find tissues and cell lines supported by DNA array analysis to express MTA2. 
RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express MTA2. 
Protein Interactions:vpr; SUMO2; SUMO3; DNMT3B; DNMT1; NACC2; ZBTB16; UBC; RARA; ZBTB1; RNF2; GPHN; HNRNPR; TRIM28; PPP4R1; ROCK2; SPAG9; POLR2C; POLR2A; MAP4; RPP25; LSM8; GET4; LARP7; CD2AP; NR3C1; MTOR; EHBP1L1; RABEP2; BRCC3; SMEK1; ZGPAT; HDAC1; HDAC2; CSNK1E; MTA3; UBE3 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
