Tested Species Reactivity:HumanProduct Format:Liquid. Supplied in 1% BSA, 0.05M Tris-HCl, 0.15M NaCl, 0.2% Kathon CG/ICP, 0.1% Tween-20Clonality:Monoclonal Clone:ABT-P1Isotype:IgGHost:MouseApplication:IHC-PAdditional Information:Retrieval buffer: Citrate buffer of pH6.0:::Description: Mouse monoclonal to PerforinReconstitution and Storage:Shipped at 4C. Store at -20C. Stable for 12 months at -20C.Immunogen:The antiserum was produced against synthesized peptide derived between 20-60 aa of human PRF1. The exact sequence is proprietary.Purification:Immunogen affinity purifiedDatasheets/Manuals:Printable datasheet for OAAF08384Specificity:Anti-Perforin [ABT-P1] detects endogenous levels of total Perforin protein.Application Info:IHC 1:200 - 1:400Gene Symbol:PRF1Official Gene Full Name:perforin 1Alias Symbols:P1, PFP, HPLH2NCBI Gene Id:5551Protein Name:perforin-1Description of Target:This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood.Swissprot Id:P14222Protein Accession #:NP_001076585.1Nucleotide Accession #:NM_005041.4Molecular Weight:61 kDaTissue Tool:Find tissues and cell lines supported by DNA array analysis to express PRF1. RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express PRF1. 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
