Predicted Species Reactivity:Human, Mouse, RatClonality:MonoclonalClone:S96-7Isotype:IgG1Host:MouseApplication:WB, IHC, IPAdditional Information:Background Info: Detects ~70kDa (Pancortin-1,Pancortin-3) and ~20kDa(Pancortin-2 and Pancortin-4).:::Scientific Background: Pancortin, a member of a diverse family of secreted glycoproteins, is implicated in the development of thenervous system, and the glaucoma-associated proteinmyocilin (1).Studies suggest that Pancortin-2 interact with WAVE1 ina novel cell death cascade in adult, but not embryonic,cerebral cortical neurons. Specifically pancortin-2 is amediator of ischemia-induced apoptosis of neurons in theadult cerebral cortex, and functions in a novelmitochondrial/actin associated protein complex thatsequesters Bcl-xL (2).It is also involved in the generation of neural crest cells,and in neurogenesis (3-4).:::Certificate of Analysis: 1ug/mL was sufficient for detection of Pacortins in 20ug of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.Reconstitution and Storage:Store at -20C. Shipping in Blue Ice or 4C.Replacement Item:This antibody may replace item sc-130179 from Santa Cruz Biotechnology.Immunogen:Synthetic peptide of amino acids 28-48 of human pancortin-1 (SLVGLNTTRLSAASGGTLDRS), accession number Q99784.Purification:Protein G PurifiedConcentration:1mg/mLDatasheets/Manuals:Printable datasheet for OASE00230Dilution:1ug/mL (WB), 0.1-1ug/mL (IHC/ICC), 1-10ug/mL (IF)Storage Buffer:PBS pH7.4, 50% glycerolTarget Reference:1. Lee J.A., Anhold R.R.H., and Cole G.J. (2008) Mech Dev.125(1-2): 167-181.2. Cheng A., et al. (2007) J Neurosci. 27(7): 1519-1528.3. Barembaum M., et al. (2000) Nat Cell Biol. 2: 219-225.4. Moreno T.A., and Bronner-Fraser M. (2001) Dev Biol.240: 340-360.Gene Symbol:Olfm1Official Gene Full Name:olfactomedin 1NCBI Gene Id:56177Swissprot Id:O88998Protein Accession #:NP_001033701.1Tissue Tool:Find tissues and cell lines supported by DNA array analysis to express Olfm1. RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express Olfm1. 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
