Tested Species Reactivity:HumanPredicted Species Reactivity:HumanProduct Format:Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.Clonality:PolyclonalHost:RabbitApplication:WBReconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Gene Symbol:NISCHOfficial Gene Full Name:nischarinNCBI Gene Id:11188Protein Name:NischarinSwissprot Id:Q9Y2I1-2Protein Accession #:NP_001263222.1Nucleotide Accession #:NM_001276293.1Alias Symbols:I-1, IR1, IRAS, hIRASDescription of Target:This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor.Protein Size (# AA):993Molecular Weight:109 kDaPurification:Affinity purifiedTissue Tool:Find tissues and cell lines supported by DNA array analysis to express NISCH. 
RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express NISCH. 
Immunogen:The immunogen is a synthetic peptide directed towards the C terminal region of human NISCHPeptide Sequence:Synthetic peptide located within the following region: LLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTConcentration:Batch dependent within range: 100 ul at 0.5 - 1 mg/mlBlocking Peptide:For anti-NISCH (ARP87533_P050) antibody is Catalog # AAP87533Datasheets/Manuals:Printable datasheet for anti-NISCH (ARP87533_P050) antibody 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
