Magnosphere MS300/Streptavidin particles are streptavidin-coated magnetic microparticles of uniform size that are intended for recovery of biotin-labeled molecules. Magnosphere MS300/Streptavidin particle surfaces are covered with a hydrophilic polymer, enabling low non-specific absorption of nucleic acids and no inhibition of enzymatic activity. These Magnosphere MS300/Streptavidin magnetic microparticles can be used in PCR and qPCR amplifications or with ELISA systems.