Predicted Species Reactivity:Cow, Dog, Human, Mouse, Rat, ZebrafishProduct Format:Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.Clonality:PolyclonalHost:RabbitApplication:WBAdditional Information:Packaging : 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.Reconstitution and Storage:For long term storage -20C is recommended. Stable at -20C for at least 1 year.Gene Symbol:GABRA2NCBI Gene Id:61856Protein Name:Gamma-aminobutyric acid receptor subunit alpha-2Swissprot Id:P23576Replacement Item:This antibody may replace item sc-133602 from Santa Cruz Biotechnology.Description of Target:Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alpha s, four beta s and four gamma s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha - and beta -subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma -subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha -subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).Molecular Weight:~51kDaPurification:Prepared from rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.Tissue Tool:Find tissues and cell lines supported by DNA array analysis to express GABRA2. 
RNA Seq:Find tissues and cell lines supported by DNA array analysis to express GABRA2. 
Immunogen:Fusion protein from the cytoplasmic loop of the alpha 2-subunit of rat GABAA receptor.Predicted Homology Based on Immunogen Sequence:Cow; Dog; Human; Mouse; Rat; ZebrafishDatasheets/Manuals:Printable datasheet for OAPC00120Specificity:Specific for the ~51k alpha 2-subunit of the GABAA receptor in Western blots. Labeling is absent in alpha 2-subunit knockout animals. 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
