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Background: cGMPisaubiquitoussecondmessengermediatingcellularresponsestovariousexogenousandendogenoussignalingmolecules.cGMPregulatesphysiologicalprocessesbyactivatingproteinkinases,gatingspecificionchannels,andmodulatingcellularcyclic

Immunogen: cGMP

Applications: ELISA,WB,IHC

RecommendedDilutions: ELISA1:1000-1:5000,WB1:1000-1:2000

Host: mouse

Format: Liquid

Clonality: Monoclonal

Isotype: IgG

Purity: Purifiedfromascites

Storagebuffer:

Preservative: no

Constituents: PBS(withoutMg²⁺andCa²⁺),pH7.4,150mMNaCl,50%glycerol

SpeciesReactivity:

StorageConditions: Storeat-20°C.Avoidfreeze/thawcycles

DownloadDatasheet:

FAQsDatasheet:

TypicalStandardCurves

Sensitivity AcetylatedVersion

MeanODforBo=0.536±0.010

MeanODforStandard#6=0.403±0.009

DeltaOpticalDensity(0-0.08pmol/mL)=0.133

2SD"softheZeroStandard=0.020

Sensitivity=(0.020/0.133)*0.08pmol/mL=12fmol/mL


RelatedProducts
Catalog#	Name	Size	Price	DataSheet
26001-1	Anti-cGMPMouseMonoclonalAntibody	30μL	$330
80103	MonoclonalAnti-cGMPEIAKitwithoutAcetylation	1x96well	$385
80104	MonoclonalAnti-cGMPEIAKitwithoutAcetylation	5x96well	$1595
26002-1	Anti-cAMPMouseMonoclonalAntibody	30μL	$330
80203	MonoclonalAnti-cAMPEIAKitwithoutAcetylation	1x96well	$385
80204	MonoclonalAnti-cAMPEIAKitwithoutAcetylation	5x96well	$1595

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Publications:

1. Sulfhydryl-dependentdimerizationofsolubleguanylylcyclasemodulatestherelaxationofporcinepulmonaryarteriestonitricoxide PflugersArch.2013Feb;465(2):333-41

2. Pressure-overload-inducedsubcellularrelocalization/oxidationofsolubleguanylylcyclaseintheheartmodulatesenzymestimulation CircRes.2012Jan20;110(2):295-303

3. Natriureticpeptidesblocksynaptictransmissionbyactivatingphosphodiesterase2AandreducingpresynapticPKAactivity ProcNatlAcadSciUSA.2012Oct23;109(43):17681-6

4. Roleofsulfhydryl-dependentdimerizationofsolubleguanylylcyclaseinrelaxationofporcinecoronaryarterytonitricoxide CardiovascRes.2011Jun1;90(3):565-72

5. Molt-inhibitinghormonefromChinesemittencrab(Eriocheirsinensis):Cloning,tissueexpressionandeffectsofrecombinantpeptideonecdysteroidsecretionofYOs GenCompEndocrinol.2011Sep15;173(3):467-74

6. InhibitionofStriatalSolubleGuanylylCyclase-cGMPSignalingReversesBasalGangliaDysfunctionandAkinesiainExperimentalParkinsonism PLoSOne.2011;6(11):e27187

7. Molecularanalysis,developmentalfunctionandheavymetal-inducedexpressionofABCC5inzebrafish CompBiochemPhysiolBBiochemMolBiol.2011Jan;158(1):46-55

8. FeedbackcontrolthroughcGMP-dependentproteinkinasecontributestodifferentialregulationandcompartmentationofcGMPinratcardiacmyocytes CircRes.2010Nov12;107(10):1232-40

9. TheSolubleGuanylateCyclaseActivatorBAY58-2667ProtectsagainstMorbidityandMortalityinEndotoxicShockbyRecouplingOrganSystems PLoSOne.2013Aug28;8(8):e72155

10. Stimulationofguanylylcyclase-Dbybicarbonate Biochemistry.2009May26;48(20):4417-22

11. Volumeoverloadinducesdifferentialspatiotemporalregulationofmyocardialsolubleguanylylcyclaseineccentrichypertrophyandheartfailure JournalofMolecularandCellularCardiologyVolume60,July2013,Pages72–83

12. DefiningSpecificityDeterminantsofCyclicGMP-MediatedGustatorySensoryTransductioninCaenorhaBDitiselegans genetics.113.152660v1194/4/885

13. Theroleofnitricoxidesignalinginfoodintake;insightsfromtheinnermitochondrialmembranepeptidase2mutantmice RedoxBIOLOGyVolume1,Issue1,2013,Pages498–507

14. CrossregulationbetweencGMP-dependentproteinkinaseandAktinvasodilatationofporcinepulmonaryartery JournalofCardiovascularPharmacology:November2014-Volume64-Issue5-p452-459

15. Geneticablationofsolutecarrierfamily7a3aleadstohepaticsteatosisinzebrafishduringfasting HepatologyVolume60,Issue6,pages1929–1941,December2014