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商品描述
| Catalog Number: 26071 |
| Gene Symbol: RIC8A |
| Description: Anti-Ric-8A Mouse Monoclonal Antibody |
| Background: Ric-8A (Resistance to Inhibitors of Cholinesterase-8A) interacts with Gαo, Gαi, Gαq and Gα13, but not Gαs, proteins. Mammalian Ric-8A protein is a guanine nucleotide exchange factor for Gαq, Gαi, Gαo, Gα12, Gα13, but not for Gαs. C. elegans Ric8 (also named Synembryn) is required for proper asymmetric division of 1-cell-stage embryos. Ric8 is required for the generation of substantial pulling forces on astral microtubules. |
| Immunogen: A synthetic peptide near the C-terminus of Ric-8A, human origin. |
| Applications: ELISA, WB, IHC, IP |
| Recommended Dilutions: ELISA: 1:100-1:5000 WB: 1:100-1:2000 IHC: 1:50-1:100 |
| Concentration: 1 mg/ml |
| Host: mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: IgG |
| Purity: Purified from ascites |
| Storage buffer: |
| Preservative: no |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Ric-8A antibody recognizes Ric-8A from vertebrates. |
| Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles |
Download Datasheet:  |
| Western blot: |
| | Western blot analysis of Ric-8A proteins. Whole-cell lysate of HeLa cells was blotted with anti-Ric-8A monoclonal antibody (Cat. #26071). |
| Publications: |
| 1. Atypical Protein Kinase Cλ is Critical for Growth Factor Receptor-Induced Dorsal Ruffle Turnover and Cell Migration J Biol Chem. 2013 Nov 15;288(46):32827-36 |
