1)广西科技大学生物与化学工程学院, 广西 柳州545006; 2)广西柳州市疾病预防控制中心, 广西 柳州545006 1) College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545006, Guangxi,China; 2) Liuzhou Municipal Centers for Disease Control and Prevention, Liuzhou 545006, Guangxi,China 摘要5-脂氧合酶（5-lipoxygenase, 5-LOX）是生物体内一种重要的双加氧酶.5-LOX是催化花生四烯酸（arachidonic acid，AA）生成白三烯类（leukotrienes, LTs）的关键酶. LTs是重要的炎症介质，并且在许多疾病中发挥着重要作用.近年来,很多学者致力于5LOX的研究，从而为5-LOX抑制剂的研发提供理论依据.本文对5-LOX的分子结构、细胞内定位、表达与活性调控及其抑制剂的研究进展进行综述. Abstract：The 5-lipoxygenase（5-LOX）is an important dioxygenase in organisms, which is the key enzyme catalyzing arachidonic acid into leukotrienes (LTs). LTs is a potent mediator of the inflammatory response and plays important roles in many diseases. 5-LOX has a single polypeptide chain with a molecular mass of 75-80 kD and 673 amino acid residues in animals, which has a Nterminal barrel domain and a larger catalytic domain containing a single atom of non-heme iron. 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