Ciliary Neurotrophic Factor, or CNTF, is a neurotrophic factorthat promotes the survival of various neuronal cell types and mayplay an important role in the injury response in the nervoussystem. CNTF, like FGF acidic, FGF basic, and PD-ECGF(platelet-derived endothelial cell growth factor), does notpossess a signal sequence that would allow secretion of thefactor by classical secretion pathways (endoplasmaticreticulum/Golgi system), but the mechanism underlying the releaseof CNTF is unknown.Recombinant human CNTF is a non-glycosylatedprotein, contains 199 amino acids, with a molecular mass of 22.7kDa.
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