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蚂蚁淘在线 / 品牌中心 / Encapsula / Encapsula/ImmunoFluor™-NHS (PEGylated) (Post-insertion)/2-ml/IMF-3004

Encapsula/ImmunoFluor™-NHS (PEGylated) (Post-insertion)/2-ml/IMF-3004

价格
￥19000.00
货号：IMF-3004
浏览量：116
品牌：Encapsula
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商品描述

Numeroustechniqueshavebeendevelopedtoprepareimmunoliposomesbasedonthenucleophilicreactivityoffreeaminegroupsofproteinsorpeptides.However,themostcommon,versatileandstraightforwardactivationchemistryforcreatingreactiveacylatingreagentsandlabelingpeptides/proteinsistoformNHSesterwithprimaryamines.AsinglestepnucleophilicsubstitutionreactionbetweenNHSesterderivativeandalphaaminesattheNterminalorthebetaaminesoflysinesidechainsleadstotheformationofastableamidebond.

N-Hydroxysuccinimide(NHS)estersofDSPE-PEG-NHSliposomesreactwiththeprimaryaminegroupsonthepeptides,proteins,antibodiesorotherfunctionalligandsfortargeteddrugdeliveryapplications.ThenucleophilicattackoftheaminegroupsontheNHS-activatedcarbonylgroupoftheDSPE-PEG-NHSresultsintheeliminationoftheNHSgroupandformationofamidelinkage.

ConjugationreactionbetweenNHS-activatedDSPE-PEGlipidwiththeaminegroupofligandandformationofstableamidelinkage.Themicellesformedfromlipidconjugatedligandandnon-reactivePEGlipidsaremixedtogetherandthePEGylatedlipidsarepost-insertedintotheliposomestoformPEGylatedligandsurfaceconjugatedliposomes.

ImmunoFluor™-NHSisaPEGylatedproduct.Forotheraminereactive(PEGylatedandnon-PEGyalated)productsandalsoImmunoFluor™productssuitableforothertypesofconjugationmethodsseehere.