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April 2020 Neurobiology of Aging: Resveratrol-mediated cleavage of amyloid β1-42 peptide; potential relevance to Alzheimer’s disease | Beta Amyloid Products
April 2020 Journal of Biological Chemistry: Metal ion coordination delays amyloid-β peptide self-assembly by forming an aggregation-inert complex | Beta Amyloid Products
March 2020 Journal of Functional Food: Impact of Ecklonia radiata extracts on the neuroprotective activities against amyloid beta (Aβ1-42) toxicity and aggregation | Beta Amyloid Products
December 2019 Food & Function: Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T α-synuclein mouse model of Parkinson\'s disease | Synuclein Products
September 2019 Molecular and Cellular Neuroscience: Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice | Beta Amyloid Products
August 2019 Journal of Neurochemistry: Marine bacterial extracts as a new rich source of drugs against Alzheimer’s disease. | Beta Amyloid Products
August 2019 bioRxiv: Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease | Beta Amyloid Products
August 2019 J Alzheimers Dis.: Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer’s Disease. | Tau Products
August 2019 J Alzheimers Dis.: Toxicity of Amyloid-β Peptides Varies Depending on Differentiation Route of SH-SY5Y Cells. | Beta Amyloid Products
August 2019 Alzheimers Dement.: Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model. | Synuclein Products
August 2019 Molecular and Cellular Endocrinology: Aldosterone, STX and amyloid-β1-42 peptides modulate GPER (GPR30) signalling in an embryonic mouse hippocampal cell line (mHippoE-18). | Beta Amyloid Products
August 2019 FASEB J.: TREM2 deficiency aggravates α-synuclein–induced neurodegeneration and neuroinflammation in Parkinson’s disease models. | Synuclein Products
July 2019 Animals (Basel).: Effects of a Nutritional Supplement on Cognitive Function in Aged Dogs and on Synaptic Function of Primary Cultured Neurons | Beta Amyloid Products
July 2019 Hum Mol Genet.: Functionalization of the TMEM175 p.M393T Variant as a risk factor for Parkinson Disease. | Synuclein Products
July 2019 J Biol Chem.: Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation. | Tau Products
July 2019 Annals of Neurology: Increased Immune Activation by Pathologic α‐Synuclein in Parkinson\'s Disease | Synuclein Products
June 2019 Mol Neurobiol.: Influence of Matrix Metallopeptidase 9 on Beta-Amyloid Elimination Across the Blood-Brain Barrier. | Beta Amyloid Products
June 2019 Neurosci. Bull.: Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells. | Beta Amyloid Products
June 2019 Journal of Parkinson\'s Disease: Reduction of Immunoreactivity Against the C-Terminal Region of the Intracellular α-Synuclein by Exogenous α-Synuclein Aggregates: Possibility of Conformational Changes. | Synuclein Products
June 2019 Neuroscience Letters: Effect of naturally occurring α-synuclein-antibodies on toxic α-synuclein-fragments | Synuclein Products
May 2019 Theranostics: Highly sensitive quantification of Alzheimer\'s disease bioMarkers by aptamer-assisted amplification | Tau Products
May 2019 Theranostics.: Highly sensitive quantification of Alzheimer\'s disease biomarkers by aptamer-assisted amplification | Beta Amyloid Products
May 2019 Mol Neurobiol.: Interferon-γ Potentiates α-Synuclein-induced Neurotoxicity Linked to Toll-like Receptors 2 and 3 and Tumor Necrosis Factor-α in Murine Astrocytes. | Synuclein Products
May 2019 ACS Chem. Neurosci.: Identification of a New α-Synuclein Aggregation Inhibitor via Mass Spectrometry Based Screening | Synuclein Products
May 2019 NeuroImage: Imaging beta amyloid aggregation and iron accumulation in Alzheimer\'s disease using quantitative susceptibility mapping MRI | Beta Amyloid Products
May 2019 J. Am. Chem. Soc.: Native Ion Mobility-Mass Spectrometry Reveals the Formation of β-Barrel Shaped Amyloid-β Hexamers in a Membrane-Mimicking Environment | Beta Amyloid Products
May 2019 Mol Neurobiol.: Gedunin Inhibits Oligomeric Aβ1–42-Induced Microglia Activation Via Modulation of Nrf2-NF-κB Signaling. | Beta Amyloid Products
May 2019 Molecules.: Neuroprotective and Anti-Amyloid β Effect and Main Chemical Profiles of White Tea: Comparison Against Green, Oolong and Black | Beta Amyloid Products
May 2019 Bone: Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin | Other Products
April 2019 Dyes and Pigments: A curcumin-based NIR fluorescence probe for detection of amyloid-beta (Aβ) plaques in Alzheimer\'s disease | Beta Amyloid Products
April 2019 bioRxiv: Misfolded amyloid β-42 induced impairment of the endosomal-lysosomal pathway revealed by real-time optical monitoring | Beta Amyloid Products
April 2019 Journal of Proteome Research: Mass spectrometry-based quantification of Tau in human cerebrospinal fluid using a complementary tryptic peptide standard | Tau Products
April 2019 Journal of Proteome Research: Mass Spectrometry-Based Quantification of Tau in Human Cerebrospinal Fluid Using a Complementary Tryptic Peptide Standard | Tau Products
March 2019 Archives of Biochemistry and Biophysics: Interactions of polyunsaturated fatty acids with amyloid peptides Aβ40 and Aβ42 | Beta Amyloid Products
March 2019 Frontiers: Novel Mannitol-Based Small Molecules for Inhibiting Aggregation of α-Synuclein Amyloids in Parkinson\'s Disease | Synuclein Products
March 2019 Physical Biology: Facile single-molecule pull-down assay for analysis of endogenous proteins | Beta Amyloid Products
March 2019 Protein Science: Endosomal pH favors shedding of membrane‐inserted amyloid‐β peptide | Beta Amyloid Products
March 2019 bioRxiv: Characterization of pathology-inducing α-synuclein species from human diseased brain tissue | Synuclein Products
March 2019 Journal of Medicinal Chemistry: Proline- and Arginine-Rich Peptides as Flexible AllostericModulators of Human Proteasome Activity | Synuclein Products
March 2019 Open Biology: Protein Damage in Aging and Age-Related Diseases | Synuclein Products
March 2019 Neurochemistry International: In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ1-42) toxicity and aggregation | Beta Amyloid Products
March 2019 Anal Chem.: Electrochemical Detection of Interaction between Copper(II) and Peptides Related to Pathological α-Synuclein Mutants | Synuclein Products
March 2019 Nature Communications: ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects | Tau Products
February 2019 Scientific Reports: The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles | Beta Amyloid Products
February 2019 Future Medicinal Chemistry: Benzodifurans for biomedical applications: BZ4, a selective anti-proliferative and anti-amyloid lead compound. | Beta Amyloid Products
February 2019 Springer Berlin Heidelberg: Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity | Synuclein Products
February 2019 Humana Press, New York, NY: Measuring Mitochondrial Dysfunction Caused by Soluble α-Synuclein Oligomers | Synuclein Products
February 2019 The Journal of Nutritional Biochemistry: Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity | Synuclein Products
February 2019 Annals of Neurology: Seeding variability of different alpha synuclein strains in synucleinopathies | Synuclein Products
February 2019 bioRxiv: Stem cell derived human microglia transplanted in mouse brain to study genetic risk of Alzheimer’s Disease | Beta Amyloid Products
February 2019 BioMed Central: Dural lymphatics regulate clearance of extracellular tau from the CNS | Tau Products
February 2019 FASEB Journal: Amelioration of amyloid β-FcγRIIb neurotoxicity and tau pathologies by targeting LYN | Beta Amyloid Products
January 2019 Springer: Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson’s Disease Etiopathology | Synuclein Products
January 2019 Journal of Alzheimer\'s Disease: 17 Oxo Sparteine and Lupanine, Obtained from Cytisus scoparius, Exert a Neuroprotection against Soluble Oligomers of Amyloid-β Toxicity by Nicotinic Acetylcholine Receptors. | Beta Amyloid Products
January 2019 Journal of Alzheimer\'s Disease: 2′,3′-Dideoxycytidine, a DNA Polymerase-β Inhibitor, Reverses Memory Deficits in a Mouse Model of Alzheimer’s Disease | Beta Amyloid Products
January 2019 Nature Communications: Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes | Beta Amyloid Products
January 2019 Science Advances: Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors | Tau Products
January 2019 Journal of Neuroscience: Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses | Synuclein Products
January 2019 Hindawi: Detection of Active Caspase-3 in Mouse Models of Stroke and Alzheimer’s Disease with a Novel Dual Positron Emission Tomography/Fluorescent Tracer [68Ga]Ga-TC3-OGDOTA | Beta Amyloid Products
December 2018 PNAS: Probing the mechanism of inhibition of amyloid-β(1–42)–induced neurotoxicity by the chaperonin GroEL | Beta Amyloid Products
December 2018 IOS Press: Medical Plants and Nutraceuticals for Amyloid- Beta Fibrillation Inhibition | Beta Amyloid Products
November 2018 Scientific Reports: Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progression | Tau Products
November 2018 www.mdpi.com: Effect of Varying Concentrations of Docosahexaenoic Acid on Amyloid Beta (1–42) Aggregation: An Atomic Force Microscopy Study. | Beta Amyloid Products
November 2018 GLIA: Lipid transporter Spns2 promotes microglia pro‐inflammatory activation in response to amyloid‐beta peptide | Beta Amyloid Products
November 2018 Soft Matter: Molecular rotors report on changes in live cell plasma membrane microviscosity upon interaction with beta-amyloid aggregates | Beta Amyloid Products
November 2018 www.sciencedirect.com: Secretion of Tau via an Unconventional Non-vesicular Mechanism. | Tau Products
November 2018 Alzheimer\'s Research & Therapy: Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice. | Beta Amyloid Products
November 2018 alzres.biomedcentral.com: Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology | Beta Amyloid Products
November 2018 Springer: Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer’s disease | Beta Amyloid Products
November 2018 Prion: In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer’s brain | Tau Products
October 2018 www.sciencedirect.com: Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson\'s disease models | Synuclein Products
October 2018 ChemRxiv: Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation. | Other Products
October 2018 NCBI: Sirtuin 3 attenuates amyloid-β induced neuronal hypometabolism | Beta Amyloid Products
October 2018 Experimental Cell Research: Cerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitro. | Beta Amyloid Products
October 2018 Frontiers: Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation | Synuclein Products
September 2018 PeptideScience: L‐proline and betaine inhibit extracellular enzymes mediated abeta 1‐42 aggregation, oxidative stress, and toxicity. | Beta Amyloid Products
September 2018 www.ncbi.nlm.nih.gov: Soluble Aβ42 Acts as Allosteric Activator of the Core Cholinergic Enzyme Choline Acetyltransferase. | Beta Amyloid Products
September 2018 Journal of Biological Physics: Fe(II) formation after interaction of the amyloid β-peptide with iron-storage protein ferritin | Beta Amyloid Products
September 2018 journals.plos.org: Impaired hepatic amyloid-beta degradation in Alzheimer’s disease. | Beta Amyloid Products
September 2018 Journal of the American Society for Mass Spectrometry: Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein. | Beta Amyloid Products
September 2018 FASEB Journal: Monitoring α-synuclein multimerization in vivo. | Synuclein Products
September 2018 bioRxiv: Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-LysosomalPathway in Tauopathy | Tau Products
August 2018 journals.plos.org: Extending the functional characteristics of naturally occurring autoantibodies against β-Amyloid, Prion Protein and α-Synuclein. | Beta Amyloid Products
August 2018 PLOS ONE: Extending the functional characteristics of naturally occurring autoantibodies against β-Amyloid, Prion Protein and α-Synuclein | Synuclein Products
August 2018 www.ncbi.nlm.nih.gov: Ginkgo biloba L. (Ginkgoaceae) Leaf Extract Medications From Different Providers Exhibit Differential Functional Effects on Mouse Frontal Cortex Neuronal Networks. | Beta Amyloid Products
August 2018 Advanced Functional Materials banner: Photoactive Bismuth Vanadate Structure for Light‐Triggered Dissociation of Alzheimer\'s β‐Amyloid Aggregates | Beta Amyloid Products
August 2018 www.ncbi.nlm.nih.gov: The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction. | Beta Amyloid Products
August 2018 Molecular Neurobiology: Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt–Jakob Disease and Synucleinopathy | Synuclein Products
July 2018 Springer US: Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity | Beta Amyloid Products
July 2018 The Journal of the Alzheimer\'s Association: NON-ALZHEIMER’S DISEASE SUBJECTS OCCASIONALLY MIMIC CSF PATTERN OF PRECLINICAL ALZHEIMER’S DISEASE | Beta Amyloid Products
July 2018 Elsevier: COMMUNICATION ON DIAGNOSTIC TESTING FOR (ALZHEIMER’S) DEMENTIA: THE ABIDE-CLINICAL ENCOUNTER STUDY | Beta Amyloid Products
July 2018 www.ncbi.nlm.nih.gov: Inhibition of Phosphodiesterase-4 Reverses Aβ-Induced Memory Impairment by Regulation of HPA Axis Related cAMP Signaling. | Beta Amyloid Products
June 2018 cell.com: Genetically Engineered iPSC-Derived FTDP-17 MAPTNeurons Display Mutation-Specific Neurodegenerativeand Neurodevelopmental Phenotypes | Tau Products
June 2018 Biochim Biophys Acta Mol Basis Dis: Identification of prion protein-derived peptides of potential use in Alzheimer\'s disease therapy. | Beta Amyloid Products
June 2018 www.frontiersin.org: Preventing P-gp Ubiquitination Lowers Aβ Brain Levels in an Alzheimer’s Disease Mouse Model. | Beta Amyloid Products
June 2018 Amyloid Proteins: Luminescent-Conjugated Oligothiophene Probe Applications for Fluorescence Imaging of Pure Amyloid Fibrils and Protein Aggregates in Tissues. | Beta Amyloid Products
June 2018 Science Direct: Aβ-oligomer uptake and the resulting inflammatory response in adult human astrocytes are precluded by an anti-Aβ single chain variable fragment in combination with an apoE mimetic peptide | Beta Amyloid Products
June 2018 IOS Press: Amyloid-β/Drug Interactions from Computer Simulations and Cell-Based Assays | Beta Amyloid Products
June 2018 Journal of The Electrochemical Society: Anti-Tau Antibodies Based Electrochemical Sensor for Detection ofTau Protein Biomarkers | Tau Products
June 2018 link.springer.com: Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity. | Beta Amyloid Products
June 2018 ACS Omega: Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model | Beta Amyloid Products
May 2018 Eur J Neurosci.: α‐Synuclein activates innate immunity but suppresses interferon‐γ expression in murine astrocytes. | Synuclein Products
May 2018 Bioorganic & Medicinal Chemistry: Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine. | Beta Amyloid Products
April 2018 BioMedCentral: Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression | Beta Amyloid Products
April 2018 link.springer.com: Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson’s Disease Etiopathology | Synuclein Products
April 2018 www.hindawi.com: Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome | Beta Amyloid Products
April 2018 Science Direct: Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway | Synuclein Products
April 2018 http://journals.plos.org: High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development | Tau Products
April 2018 JBC: Inflammation-induced Iron Transport and Metabolism by Brain Microglia. | Beta Amyloid Products
March 2018 Journal of Materials Chemistry B: CLPFFD–PEG functionalized NIR-absorbing hollow gold nanospheres and gold nanorods inhibit β-amyloid aggregation. | Beta Amyloid Products
March 2018 https://avs.scitation.org: Toward multiplexed quantification of biomolecules on surfaces using time-of-flight secondary ion mass spectrometry | Beta Amyloid Products
March 2018 iv.iiarjournals.org: Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of Sasa senanensis Rehder. | Beta Amyloid Products
February 2018 Science Direct: Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders. | Beta Amyloid Products
February 2018 Acta Biomaterialia: Light-triggered dissociation of self-assembled β-amyloid aggregates into small, nontoxic fragments by ruthenium (II) complex. | Beta Amyloid Products
February 2018 www.sciencedirect.com: Serum titers of autoantibodies against α-synuclein and tau in child- and adulthood | Tau Products
February 2018 bioRxiv: MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways | Beta Amyloid Products
February 2018 Wiley Online Library: Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer\'s disease | Beta Amyloid Products
February 2018 www.hindawi.com: A Pyridazine-Based Fluorescent Probe Targeting Aβ Plaques in Alzheimer’s Disease | Beta Amyloid Products
January 2018 Journal of Neuroinflammation: Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity | Beta Amyloid Products
January 2018 https://jneuroinflammation.biomedcentral.com: Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity | Tau Products
January 2018 onlinelibrary.wiley.com: Functional requirement for human pitrilysin metallopeptidase 1 arginine 183, mutated in amyloidogenic neuropathy | Beta Amyloid Products
January 2018 The Analyst: Kinase-loaded magnetic beads for sequential in vitro phosphorylation of peptides and proteins. | Beta Amyloid Products
January 2018 Current Alzheimer Research: Amyloid-β Inhibits PDGFβ Receptor Activation and Prevents PDGF-BB-induced Neuroprotection. | Beta Amyloid Products
January 2018 link.springer.com: Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders. | Synuclein Products
January 2018 School of Graduate Studies Electronic Theses and Dissertations: DESIGN OF ANTIOXIDANT NANOTHERAPEUTICS FOR ATTENUATION OFATHEROGENESIS AND NEUROINFLAMMATION | Synuclein Products
January 2018 Journal of Brain Research: Astrocytic glutamatergic transporters are involved in Aβ-induced synaptic dysfunction | Beta Amyloid Products
January 2018 JBC: RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. | Beta Amyloid Products
December 2017 onlinelibrary.wiley.com: Cerebrospinal fluid, plasma, and saliva in the BioFIND study: Relationships among biomarkers and Parkinson\'s disease Features. | Synuclein Products
December 2017 J Mol Neurosci.: Microglial Activation Results in Inhibition of TGF-β-Regulated Gene Expression. | Beta Amyloid Products
December 2017 www.sciencedirect.com: Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer’s disease | Tau Products
December 2017 J Chromatogr B Analyt Technol Biomed Life Sci.: An UHPLC–MS/MS method for simultaneous quantification of human amyloid beta peptides Aβ1-38, Aβ1-40 and Aβ1-42 in cerebrospinal fluid using micro-elution solid phase extraction. | Beta Amyloid Products
December 2017 Journal of Neuroimmune Pharmocology: The Ketone Body β-Hydroxybutyrate Does Not Inhibit Synuclein Mediated Inflammasome Activation in Microglia. | Synuclein Products
November 2017 Journal of Peptide Science: Dissecting the behaviour of β‐amyloid peptide variants during oligomerization and fibrillation. | Beta Amyloid Products
November 2017 https://pubs.acs.org: Comparison of Internal Standard Approaches for SRM Analysis ofAlpha-Synuclein in Cerebrospinal Fluid | Synuclein Products
October 2017 Nanomedicine: Nanotechnology, Biology and Medicine: Peptide multifunctionalized gold nanorods decrease toxicity of β-amyloid peptide in a Caenorhabditis elegans model of Alzheimer\'s disease. | Beta Amyloid Products
October 2017 PLOS ONE: In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells. | Beta Amyloid Products
October 2017 Europe PMC: P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer\'s disease. | Beta Amyloid Products
October 2017 Journal of Neuroinflammation: Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation | Beta Amyloid Products
September 2017 J Neurochem: A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid‐β oligomers. | Beta Amyloid Products
September 2017 Mol Neurobiol.: Analysis of the Impact of CD200 on Phagocytosis. | Beta Amyloid Products
September 2017 actaneurocomms.biomedcentral.com: Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease? | Synuclein Products
September 2017 Biopolymers: Tau peptides and tau mutant protein aggregation inhibition by cationic polyethyleneimine and polyarginine. | Tau Products
September 2017 Journal of Alzheimer\'s Disease: Assessment of Novel Curcumin Derivatives as Potent Inhibitors of Inflammation and Amyloid-β Aggregation in Alzheimer’s Disease. | Beta Amyloid Products
September 2017 Scientific Reports: Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways. | Beta Amyloid Products
September 2017 Chemical Science: Tuning the stereo-hindrance of a curcumin scaffold for the selective imaging of the soluble forms of amyloid beta species | Beta Amyloid Products
September 2017 Small: Carbon Nanodot‐Sensitized Modulation of Alzheimer\'s β‐Amyloid Self‐Assembly, Disassembly, and Toxicity | Beta Amyloid Products
August 2017 BMC Neurol.: Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke | Tau Products
August 2017 PLoS One: Changes in lipid membranes may trigger amyloid toxicity in Alzheimer\'s disease. | Beta Amyloid Products
August 2017 Translational Psychiatry: Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations. | Tau Products
August 2017 Journal of Alzheimer\'s Disease: Non-Phosphorylated Tau as a Potential Biomarker of Alzheimer’s Disease: Analytical and Diagnostic Characterization. | Tau Products
August 2017 PLoS One: Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles. | Synuclein Products
August 2017 Advanced Biosystems: Remodeling Tau and Prion Proteins Using Nanochaperons. | Tau Products
August 2017 Journal of Visualized Expirements: Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays. | Synuclein Products
August 2017 Biophysics and Biochemistry of Protein Aggregation: Folding and Misfolding of Amyloid-β40 and 42 in Alzheimer’s Disease. | Beta Amyloid Products
July 2017 Science Direct Bioorganic & Medicinal Chemistry: Structure-activity relationships for flavone interactions with amyloid β reveal a novel anti-aggregatory and neuroprotective effect of 2′,3′,4′-trihydroxyflavone (2-D08) | Beta Amyloid Products
July 2017 Journal of the Alzheimer\'s Association: MultiTEP platform–based DNA vaccines for alpha-synucleinopathies: pre clinical evaluation of immunogenicity and therapeutic potency | Synuclein Products
July 2017 Online Library: Endothelin‐converting enzymes degrade α‐synuclein and are reduced in dementia with Lewy bodies | Synuclein Products
July 2017 Neuroscience: Levodopa (L-DOPA) attenuates endoplasmic reticulum stress response and cell death signaling through DRD2 in SH-SY5Y neuronal cells under α-synuclein-induced toxicity. | Synuclein Products
July 2017 Hindawi: Development and Characterisation of a Novel NF-κB Reporter Cell Line for Investigation of Neuroinflammation | Beta Amyloid Products
July 2017 Journal of the Alzheimer\'s Association: PROGRESS ON THE DEVELOPMENT OF CERTIFIED REFERENCE MATERIALS FOR Aβ1-42. | Beta Amyloid Products
July 2017 Alzheimer\'s and Dementia: USE FOR CALIBRATION OF CERTIFIED REFERENCE MATERIALS FOR Aβ1-42 | Beta Amyloid Products
July 2017 Journal of Alzheimer\'s Disease: Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease. | Synuclein Products
July 2017 The NatureResearch Journal: Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson\'s disease | Beta Amyloid Products
June 2017 Journal of Inorganic Biochemistry: Covalent modifications of the amyloid beta peptide by hydroxynonenal: Effects on metal ion binding by monomers and insights into the fibril topology. | Beta Amyloid Products
June 2017 Alzheimer\'s Research & Therapy: Recommendations for cerebrospinal fluid collection for the analysis by ELISA of neurogranin trunc P75, α-synuclein, and total tau in combination with Aβ(1–42)/Aβ(1–40). | Synuclein Products
June 2017 Journal of Alzheimer\'s Disease: NFATc2 Modulates Microglial Activation in the AβPP/PS1 Mouse Model of Alzheimer’s Disease. | Beta Amyloid Products
June 2017 Journal of Alzheimer\'s Disease: CD44 Splice Variants as Potential Players in Alzheimer’s Disease Pathology | Beta Amyloid Products
June 2017 BioMedCentral: Autoimmune antibody decline in Parkinson’s disease and Multiple System Atrophy; a step towards immunotherapeutic strategies | Synuclein Products
May 2017 Springer Link Purinergic Signalling: P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells | Synuclein Products
May 2017 Clinical Interventions in aging: Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery. | Beta Amyloid Products
April 2017 Science Direct Pathology: Tau Antibody–Targeting Pathological Species Block Neuronal Uptake and Interneuron Propagation of Tau in Vitro | Tau Products
April 2017 Journal of Alzheimer\'s Disease: Apolipoprotein E Isoforms Differentially Regulate Alzheimer’s Disease and Amyloid-β-Induced Inflammatory Response in vivo and in vitro. | Beta Amyloid Products
April 2017 BioMed Central: Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer | Beta Amyloid Products
April 2017 Analytica Chimica Acta: Multivalent foldamer-based affinity assay for selective recognition of Aβ oligomers. | Beta Amyloid Products
April 2017 Journal of Neuroscience Research: Peripheral treatment with enoxaparin exacerbates amyloid plaque pathology in Tg2576 mice. | Beta Amyloid Products
April 2017 Springer Link CNS Drugs: Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer’s Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data | Beta Amyloid Products
April 2017 BioMed Central: Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein | Tau Products
April 2017 RSC Advances: Application of quinazoline and pyrido[3,2-d]pyrimidine templates to design multi-targeting agents in Alzheimer\'s disease. | Beta Amyloid Products
April 2017 J-Stage Beta: 7-(4-Hydroxyphenyl)-1-phenyl-4E-hepten-3-one, a Diarylheptanoid from Alpinia officinarum, Protects Neurons against Amyloid-β Induced Toxicity | Beta Amyloid Products
April 2017 BioMed Central: Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model | Beta Amyloid Products
March 2017 Chem Biol Drug Des.: In vitro study on potential pharmacological activity of curcumin analogues and their copper complexes. | Beta Amyloid Products
March 2017 The Febs Journal: Unmodified and pyroglutamylated amyloid β peptides form hypertoxic hetero-oligomers of unique secondary structure | Beta Amyloid Products
March 2017 The Febs Journal: Structure dependent effects of Amyloid-β on long-term memory in Lymnaea stagnalis | Beta Amyloid Products
March 2017 Biochemical and Biophysical Research Communications: 7-(4-Hydroxy-3-methoxyphenyl)-1-phenyl-4E-hepten-3-one alleviates Aβ1-42 induced cytotoxicity through PI3K-mTOR pathways. | Beta Amyloid Products
March 2017 Journal of Physical Chemistry: Potential Artifacts in Sample Preparation Methods Used for Imaging Amyloid Oligomers and Protofibrils due to Surface-Mediated Fibril Formation. | Beta Amyloid Products
February 2017 FEBS PRESS: Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid‐β 1‐42 | Beta Amyloid Products
February 2017 Neurobiology of Aging: Kalirin Reduction Rescues Psychosis-Associated Behavioral Deficits in APPswe/PSEN1dE9 Transgenic Mice | Beta Amyloid Products
February 2017 Elsevier: An extract of the marine alga Alaria esculenta modulates -synucleinfolding and amyloid formation | Synuclein Products
February 2017 Advanced HealthCare Materials: Hematite-Based Photoelectrode Materials for Photoelectrocatalytic Inhibition of Alzheimer\'s β-Amyloid Self-Assembly | Beta Amyloid Products
February 2017 Nanomedicine: Nanotechnology, Biology and Medicine: Retro-inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer\'s Aβ peptide. | Beta Amyloid Products
February 2017 Advanced Biosystems: Restoring the Processivity of Kinesin Nanomotors. | Tau Products
February 2017 Science Direct European Journal of Medicinal Chemistry: Identification of dibenzyl imidazolidine and triazole acetamide derivatives through virtual screening targeting amyloid beta aggregation and neurotoxicity in PC12 cells | Beta Amyloid Products
February 2017 Biochim Biophys Acta Mol Basis Dis.: Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer\'s disease treatment. | Beta Amyloid Products
January 2017 Science Direct Biophysical Chemistry Volume 220, January 2017, Pages 34–41: Antibodies against the C-terminus of α-synuclein modulate its fibrillation | Synuclein Products
January 2017 New Journal of Chemistry: Synthesis and evaluation of benzothiazole-triazole and benzothiadiazole-triazole scaffolds as potential molecular probes for amyloid-β aggregation. | Beta Amyloid Products
January 2017 Electrophoresis: Behavior of α‐synuclein–drug complexes during nanopore analysis with a superimposed AC field. | Synuclein Products
January 2017 Science Direct Neurochemistry International: Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways | Beta Amyloid Products
January 2017 Science Direct The International Journal of Biochemistry & Cell Biology: Amyloid-beta Peptide Decreases Expression and Function of Glutamate Transporters in Nervous System Cells | Beta Amyloid Products
January 2017 Science Direct Neuropharmacology: FTY720 (Fingolimod) reverses α-synuclein-Induced downregulation of brain-derived neurotrophic factor mRNA in OLN-93 oligodendroglial cells | Synuclein Products
January 2017 Acta Neuropathologica: Widespread tau seeding activity at early Braak stages. | Tau Products
January 2017 J Biol Inorg Chem.: Development of multifunctional heterocyclic Schiff base as a potential metal chelator: a comprehensive spectroscopic approach towards drug discovery. | Beta Amyloid Products
January 2017 Sensors and Actuators B: Chemical: Microtubule density and landing rate as parameters to analyze tau protein in the MT-kinesin \"gliding” assay | Tau Products
January 2017 Wiley Online Library: Rattle-Structured Upconversion Nanoparticles for Near-IR-Induced Suppression of Alzheimer\'s β-Amyloid Aggregation | Beta Amyloid Products
January 2017 NCBI: DOPAL is transmissible to and oligomerizes alpha-synuclein in human glial cells. | Synuclein Products
December 2016 Scientific Reports: The involvement of dityrosine crosslinking in synuclein assembly and deposition in Lewy Bodies in Parkinson\'s disease. | Synuclein Products
December 2016 FEBS Open Bio: Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1–42-mediated cytotoxicity. | Beta Amyloid Products
December 2016 Science Direct Neuroscience: Regulatory factor X1 depresses ApoE-dependent Aβ uptake by miRNA-124 in microglial response to oxidative stress | Beta Amyloid Products
December 2016 Springer Link Cellular and Molecular Neurobiology: Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein | Synuclein Products
December 2016 Scientific Reports: Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin. | Beta Amyloid Products
December 2016 Nature.com Scientific Reports: The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease | Beta Amyloid Products
December 2016 RSC Advances: Quantitative analysis of amyloid polymorphism using height histograms to correct for tip convolution effects in atomic force microscopy imaging. | Beta Amyloid Products
November 2016 Journal of Neurochem.: Reference measurement procedure for CSF amyloid beta (Aβ)1-42 and the CSF Aβ1-42 /Aβ1-40 ratio - a cross-validation study against amyloid PET. | Beta Amyloid Products
November 2016 Semantic Scholar Neuron, Volume 90: Increased 4R-Tau Induces PathologicalChanges in a Human-Tau Mouse Model | Tau Products
November 2016 Front Neurosci.: Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain. | Tau Products
November 2016 eLife 2016;5:e18691: FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer\'s disease model | Beta Amyloid Products
November 2016 EXP Neurol.: α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function. | Synuclein Products
November 2016 PLOS ONE: Naturally Occurring Autoantibodies against Tau Protein Are Reduced in Parkinson\'s Disease Dementia | Tau Products
October 2016 Journal of Alzheimer\'s Disease: Multifunctional Effect of Human Serum Albumin Reduces Alzheimer’s Disease Related Pathologies in the 3xTg Mouse Model. | Beta Amyloid Products
October 2016 Science Direct: The Alzheimer\'s-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2) | Beta Amyloid Products
October 2016 Sci Rep.: Imaging hydrogen peroxide in Alzheimer’s disease via cascade signal amplification. | Beta Amyloid Products
October 2016 Journal of Neuroimmune Pharmocology: Anti-Inflammatory and Neuroprotective Effects of PGE2 EP4 Signaling in Models of Parkinson’s Disease. | Synuclein Products
September 2016 Plos.org: Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid | Tau Products
September 2016 Journal of Alzheimer\'s Disease: ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain. | Beta Amyloid Products
September 2016 Biochemical and Biophysical Research Communications: miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer\'s disease | Tau Products
September 2016 US National Library of Medicine: Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 | Tau Products
August 2016 J Vis Exp.: Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps. | Beta Amyloid Products
August 2016 BMC Neurology: Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke. | Tau Products
August 2016 Fluids Barriers CNS: Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding | Beta Amyloid Products
August 2016 Acta Neuropathologica: Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease. | Beta Amyloid Products
August 2016 freepatentsonline: PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DEGENERATIVE BRAIN DISEASE COMPRISING MULTI-TARGETING COMPOUNDS | Beta Amyloid Products
August 2016 PLOS ONE: Effect of IVIG Formulation on IgG Binding to Self- and Exo- Antigens In Vitro and In Vivo | Beta Amyloid Products
July 2016 Parkinson’s Disease: 5-HT2A Receptor Binding in the Frontal Cortex of Parkinson’s Disease Patients and Alpha-Synuclein Overexpressing Mice: A Postmortem Study | Synuclein Products
July 2016 BioMed Central: Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner | Beta Amyloid Products
July 2016 Biomaterials: A theranostic agent for in vivo near-infrared imaging of β-amyloid species and inhibition of β-amyloid aggregation. | Beta Amyloid Products
July 2016 Phys Chem Chem Phys: Fullerenol C60(OH)16 prevents amyloid fibrillization of Aβ40 – in vitro and in silico approach. | Beta Amyloid Products
June 2016 Nature.com: Common molecular mechanism of amyloid pore formation by Alzheimer’s β-amyloid peptide and α-synuclein | Beta Amyloid Products
June 2016 Mov Disord.: Cerebrospinal fluid biomarkers and clinical features in leucine‐rich repeat kinase 2 (LRRK2) mutation carriers. | Synuclein Products
June 2016 Biochim Biophys Acta.: Characterization of insulin-degrading enzyme-mediated cleavage of Aβ in distinct aggregation states. | Beta Amyloid Products
June 2016 Science Direct: Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds | Beta Amyloid Products
May 2016 Springer Link: Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells | Beta Amyloid Products
May 2016 Science Direct: CSF Aβ1–42 – an excellent but complicated Alzheimer\'s biomarker – a route to standardisation | Beta Amyloid Products
May 2016 Analytical Biochem.: Sensitive analysis of α-synuclein by nonlinear laser wave mixing coupled with capillary electrophoresis. | Synuclein Products
May 2016 RSC Advances: Structure–activity relationships of radioiodinated diphenyl derivatives with different conjugated double bonds as ligands for α-synuclein aggregates. | Synuclein Products
May 2016 Journal of Inorganic Biochemistry: Multifunctional quinoline-triazole derivatives as potential modulators of amyloid-β peptide aggregation | Beta Amyloid Products
May 2016 Journal of Alzheimer\'s Disease: Immunization with Small Amyloid-β-derived Cyclopeptide Conjugates Diminishes Amyloid-β-Induced Neurodegeneration in Mice. | Beta Amyloid Products
May 2016 NCBI: Protein Kinase Cδ Upregulation in Microglia Drives Neuroinflammatory Responses and Dopaminergic Neurodegeneration in Experimental Models of Parkinson\'s Disease | Synuclein Products
May 2016 Alzheimer\'s & Dementia: Technical performance of a novel, fully automated electrochemiluminescence immunoassay for the quantitation of β-amyloid (1–42) in human cerebrospinal fluid. | Beta Amyloid Products
April 2016 UKnowledge: VARIANCE OF THE AMYLOID BETA PEPTIDE AS A METRIC FOR THE DIAGNOSIS OF ALZHEIMER\'S DISEASE | Beta Amyloid Products
April 2016 Journal of Biological Chemistry: Ste24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides. | Beta Amyloid Products
April 2016 Oncotarget: The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signalling. | Beta Amyloid Products
April 2016 Journal of Biological Chemistry: The Luminescent Oligothiophene p-FTAA Converts Toxic Aβ1–42 Species into Nontoxic Amyloid Fibers with Altered Properties. | Beta Amyloid Products
April 2016 Lab Chip: On-chip microtubule gliding assay for parallel measurement of tau protein species. | Tau Products
April 2016 nature.com: 82-kDa choline acetyltransferase and SATB1 localize to β-amyloid induced matrix attachment regions | Beta Amyloid Products
April 2016 Advanced Healthcare Materials: Photoactive g‐C3N4 Nanosheets for Light‐Induced Suppression of Alzheimer\'s β‐Amyloid Aggregation and Toxicity. | Beta Amyloid Products
March 2016 IOS Press: A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging | Beta Amyloid Products
March 2016 Analytical Biochemistry: Electrochemical detection of anti-tau antibodies binding to tau protein and inhibition of GSK-3β-catalyzed phosphorylation. | Tau Products
March 2016 Neurobiol Aging.: Ketones block amyloid entry and improve cognition in an Alzheimer\'s model. | Beta Amyloid Products
March 2016 ACS Publications: 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors | Synuclein Products
March 2016 Biochim Biophys Acta: Stabilization of native amyloid β-protein oligomers by Copper and Hydrogen peroxide Induced Cross-linking of Unmodified Proteins (CHICUP). | Beta Amyloid Products
March 2016 Oxford University Press: Rifampicin is a candidate preventive medicine against amyloid β and tau oligomers | Tau Products
February 2016 Free Patents Online: Methods of Treating Alzheimer\'s Disease and Other Tauopathies with Inhibitors of Microtubule Affinity Regulating Kinase | Beta Amyloid Products
January 2016 Data Brief: Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data. | Beta Amyloid Products
January 2016 PLOS ONE: Effect of Copper and Zinc on the Single Molecule Self-Affinity of Alzheimer’s Amyloid-β Peptides. | Beta Amyloid Products
January 2016 deepblue.lib: Assessment of an Initial Roadmap for Protein-Protein-Small Molecule Networks in the Brain of Alzheimer’s Disease | Beta Amyloid Products
January 2016 Inorganic Chemistry Frontiers: Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation | Beta Amyloid Products
January 2016 Neurobiology of Aging: The Ames dwarf mutation attenuates Alzheimer\'s disease phenotype of APP/PS1 mice | Beta Amyloid Products
January 2016 Stem Cell Journals: Human Cortical Neural Stem Cells Expressing Insulin‐Like Growth Factor‐I: A Novel Cellular Therapy for Alzheimer\'s Disease | Beta Amyloid Products
January 2016 Stem Cells Translational Medicine: Tissue Engineering and Regenerative Medicine Human Cortical Neural Stem Cells Expressing Insulin- Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer’s Disease | Beta Amyloid Products
January 2016 Bioorg Med Chem: Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids. https://doi.org/10.1016/j.bmc.2015.12.021 | Beta Amyloid Products
January 2016 Front Aging Neurosci.: Hippocampal Injections of Oligomeric Amyloid β-peptide (1–42) Induce Selective Working Memory Deficits and Long-lasting Alterations of ERK Signaling Pathway. | Beta Amyloid Products
January 2016 Springer: Pramlintide Antagonizes Beta Amyloid (Aβ)- and Human Amylin-Induced Depression of Hippocampal Long-Term Potentiation | Beta Amyloid Products
January 2016 Brain: Amyloid-b peptides act as allosteric modulators of cholinergic signalling through formation of soluble BA b ACs. | Beta Amyloid Products
January 2016 BioMed Central: Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta | Beta Amyloid Products
January 2016 deepblue.lib: Biophysical Insights into the Role of Amyloid-Beta Misfolding in Alzheimer’s Disease Pathogenesis | Beta Amyloid Products
January 2016 Microbial Cell: Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs | Beta Amyloid Products
January 2016 Autonomic Neuroscience: DOPAL is transmissible to and oligomerizes alpha-synuclein in human glial cells | Synuclein Products
December 2015 Plos One: Lysosomal Enzyme Glucocerebrosidase Protects against A[Beta]1-42 Oligomer-Induced Neurotoxicity: e0143854 | Beta Amyloid Products
December 2015 Science Direct: Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides | Beta Amyloid Products
December 2015 BioMed Central: Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons | Synuclein Products
November 2015 Charles University: Tau protein, a biomarker of Alzheimer´s disease: in vitro phosphorylation and tau-reactiveantibodies characterization. | Tau Products
November 2015 Science Direct: Protective properties of lysozyme on β-amyloid pathology: implications for Alzheimer disease | Beta Amyloid Products
November 2015 Metallomics: Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer\'s disease. | Beta Amyloid Products
November 2015 Oxford University Press: Amyloid-β peptides act as allosteric modulator of cholinergic signalling through formation of soluble BAβACs | Beta Amyloid Products
November 2015 Journal of Biological Chemistry: Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell-Surface Glutamate Receptors by a Mechanism that Requires EphB2′s PDZ-binding Motif and Neuronal Activity | Beta Amyloid Products
November 2015 The Journal of Neuroscience: The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment | Beta Amyloid Products
October 2015 Nature: Depletion of microglia and inhibition of exosome synthesis halt tau propagation | Tau Products
October 2015 Science Direct: Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product | Tau Products
October 2015 Molecular and Cellular Biology: Regulation of Neuronal Cell Cycle and Apoptosis by miR-34a | Beta Amyloid Products
October 2015 Science Direct: A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity | Beta Amyloid Products
October 2015 Science Direct: Insulin-degrading enzyme is activated by the C-terminus of α-synuclein | Synuclein Products
October 2015 ScienceDirect: Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer\'s Disease | Beta Amyloid Products
October 2015 Science Direct: Europium as an inhibitor of Amyloid-β(1-42) induced membrane permeation | Beta Amyloid Products
October 2015 Wiley Online Library: Altered Alpha-Synuclein, Parkin, and Synphilin Isoform Levels in Multiple System Atrophy Brains | Synuclein Products
September 2015 Cambridge University Press: A Maple Syrup Extract Prevents β-Amyloid Aggregation | Beta Amyloid Products
September 2015 PLOS One: Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer’s Disease Pathology | Beta Amyloid Products
September 2015 ACS Chemical: Drugs which bind to alpha-synuclein. Neuroprotective or neurotoxic? | Synuclein Products
September 2015 ScienceDirect: Protective properties of lysozyme on β-amyloid pathology; implications for Alzheimer disease | Beta Amyloid Products
September 2015 PLOS One: The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins | Beta Amyloid Products
September 2015 Oxford Journals: Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson\'s disease | Synuclein Products
September 2015 Free Patents Online: QUANTIFICATION OF TAU IN BIOLOGICAL SAMPLES BY IMMUNOAFFINITY ENRICHMENT AND MASS SPECTROMETRY | Tau Products
September 2015 ScienceDirect: Effect of methionine-35 oxidation on the aggregation of amyloid-β peptide | Beta Amyloid Products
September 2015 Free Patents Online: HUMAN ANTI-TAU ANTIBODIES | Tau Products
September 2015 Cornell University Library: Time dynamics of photothermal vs optoacoustic response in mid IR nanoscale biospectroscopy | Beta Amyloid Products
September 2015 Free Patents Online: METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER\'S DISEASE | Beta Amyloid Products
September 2015 ScienceDirect: Insulin-degrading enzyme is activated by the C-terminus of α-synuclein | Synuclein Products
August 2015 Springer Link: Inhibitory Effect of β-Casein on the Amyloid Fibril Formation of Aβ1–40 Associated with Alzheimer’s Disease | Beta Amyloid Products
August 2015 ScienceDirect: Brain-derived neurotrophic factor and TrkB expression in the \"oldest-old,” the 90+ Study: correlation with cognitive status and levels of soluble amyloid-beta | Tau Products
August 2015 RSC Advances: DMSO affects Aβ1–40\'s conformation and interactions with aggregation inhibitors as revealed by NMR | Beta Amyloid Products
August 2015 Neurobiol. Aging: CREB expression mediates amyloid β-induced basal BDNF downregulation. | Beta Amyloid Products
August 2015 ScienceDirect: Cu(II) promotes amyloid pore formation | Beta Amyloid Products
August 2015 ScienceDirect: Alpha-synuclein immunoreactivity patterns in the enteric nervous system | Synuclein Products
August 2015 SPIE: A new molecular model for Congo Red-β amyloid interaction: implications for diagnosis and inhibition of brain plaque formation in Alzheimer’s disease | Beta Amyloid Products
August 2015 Springer Link: A novel tau mutation, p.K317N, causes globular glial tauopathy | Tau Products
July 2015 Springer Link: Stabilization of Alpha-Synuclein Oligomers In Vitro by the Neurotransmitters, Dopamine and Norepinephrine: The Effect of Oxidized Catecholamines | Synuclein Products
July 2015 ISO Press: Development of Immunoassays for the Quantitative Assessment of Amyloid-β in the Presence of Therapeutic Antibody: Application to Pre-Clinical Studies | Beta Amyloid Products
July 2015 Publishing Journals, books and databases: Physical Chemistry Chemical Physics | Beta Amyloid Products
July 2015 Physical Chemistry Chemical Physics: Isotope-edited FTIR reveals distinct aggregation and structural behaviors of unmodified and pyroglutamylated amyloid β peptides | Beta Amyloid Products
July 2015 PLOS ONE: Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis | Beta Amyloid Products
July 2015 Alzheimer\'s Association: Round robin test on quantification of amyloid-β 1–42 in cerebrospinal fluid by mass spectrometry | Beta Amyloid Products
July 2015 Journal of the Alzheimers Disease: Additive Impairment of Synaptic Signaling in Cultured Cortical Neurons by Exogenously-Applied Oligomerized Amyloid-β and Airborne Nanoparticles Generated during Photocopying | Beta Amyloid Products
July 2015 JNC Journal of Neurochemistry: Tissue transglutaminase-catalysed cross-linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E\'s protective effects towards amyloid-beta-induced toxicity | Other Products
July 2015 JNC Journal of Neurochemistry: Tissue transglutaminase-catalysed cross-linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E\'s protective effects towards amyloid-beta-induced toxicity | Beta Amyloid Products
July 2015 Annals of Neurology: Age and amyloid effects on human central nervous system amyloid-beta kinetics | Beta Amyloid Products
July 2015 Nature: High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification | Beta Amyloid Products
July 2015 Neurobiol. Aging: P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation. | Synuclein Products
June 2015 PLOS ONE: NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes | Beta Amyloid Products
June 2015 IOS Press: Development of Immunoassays for the Quantitative Assessment of Amyloid-β in the Presence of Therapeutic Antibody: Application to Pre-Clinical Studies | Beta Amyloid Products
June 2015 The Journal of Physical Chemistry: Structural Evidence of Amyloid Fibril Formation in the Putative Aggregation Domain of TDP-43 | Beta Amyloid Products
June 2015 PLOS One: Amyloid Properties of the Mouse Egg Zona Pellucida | Beta Amyloid Products
June 2015 Free Patents Online: Curcumin Analogs | Beta Amyloid Products
June 2015 JNC Journal of Neurochemistry: Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity | Synuclein Products
June 2015 ScienceDirect: Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors | Synuclein Products
June 2015 The Journal of Biological Chemistry: α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease | Synuclein Products
June 2015 JBC Papers in Press: Alpha Synuclein Shows High-Affinity Interaction with Voltage-Dependent Anion Channel Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease | Synuclein Products
May 2015 ACS Publications: Histone H1 Favors Folding and Parallel Fibrillar Aggregation of the 1–42 Amyloid-β Peptide | Beta Amyloid Products
May 2015 AIP Advances: In vitro fibrillization of Alzheimer’s amyloid-β peptide (1-42) | Beta Amyloid Products
May 2015 Free Patents Online: 3 - (1\' - ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | Beta Amyloid Products
May 2015 Wiley Online Library: The blood clotting Factor XIIIa forms unique complexes with amyloid-beta (Aβ) and colocalizes with deposited Aβ in cerebral amyloid angiopathy | Beta Amyloid Products
May 2015 ACS Publications: Complex System Assembly Underlies a Two-Tiered Model of Highly Delocalized Electrons | Beta Amyloid Products
May 2015 ScienceDirect: A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity | Beta Amyloid Products
May 2015 Neurobiology of Aging: Comparative Pathobiology of Aβ and the Unique Susceptibility of Humans to Alzheimer’s Disease | Beta Amyloid Products
May 2015 Springer Link: Development of fluorescent probes that bind and stain amyloid plaques in Alzheimer’s disease | Beta Amyloid Products
May 2015 Springer US: Endogenous Docosahexaenoic Acid (DHA) Prevents Aβ1–42 Oligomer-Induced Neuronal Injury | Beta Amyloid Products
April 2015 ScienceDirect: ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of β-amyloid peptide in hippocampal neurons | Beta Amyloid Products
April 2015 PLOS ONE: Decrease in Plasma Levels of α-Synuclein Is Evident in Patients with Parkinson’s Disease after Elimination of Heterophilic Antibody Interference | Beta Amyloid Products
March 2015 FreePatents: CURCUMIN DERIVATIVES FOR AMYLOID-BETA PLAQUE IMAGING | Beta Amyloid Products
March 2015 Neurobiol. Aging: A noninflammatory immune response in aged DNA Aβ42-immunized mice supports its safety for possible use as immunotherapy in AD patients. | Beta Amyloid Products
March 2015 PLOS One: Amyloid Precursor Protein Mediated Changes in Intestinal Epithelial Phenotype In Vitro | Beta Amyloid Products
March 2015 The Journal of Physical Chemistry: In Silico and in Vitro Study of Binding Affinity of Tripeptides to Amyloid β Fibrils: Implications for Alzheimer’s Disease | Beta Amyloid Products
March 2015 The Journal of Biological Chemistry: Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity | Beta Amyloid Products
February 2015 Springer Link: Histamine induces the production of matrix metalloproteinase-9 in human astrocytic cultures via H1-receptor subtype | Beta Amyloid Products
February 2015 Neurobiol. Aging: Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K+ current inhibition mediated by activation of caspases and GSK-3. | Beta Amyloid Products
February 2015 British Journal of Pharmacology: The Ca2+ channel inhibitor 2-APB reverses β-amyloid-induced LTP deficit in hippocampus by blocking BAX and caspase-3 hyperactivation | Beta Amyloid Products
January 2015 The Journal of Clinical Investigation: Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models | Beta Amyloid Products
January 2015 ScienceDirect: Photo-induced inhibition of Alzheimer\'s β-amyloid aggregation in vitro by rose bengal | Beta Amyloid Products
January 2015 The Journal of Biological Chemistry: A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid β in the Brain in a Transgenic Model of Alzheimer Disease* | Beta Amyloid Products
December 2014 Curr Alzheimer Res.: Islet Amyloid Polypeptide (IAPP): A Second Amyloid in Alzheimer\'s Disease. | Beta Amyloid Products
December 2014 Acta Neuropathol Commun.: Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1. | Synuclein Products
December 2014 PLoS One: Naturally Occurring Alpha-Synuclein Autoantibodies in Parkinson’s Disease: Sources of (Error) Variance in Biomarker Assays. | Synuclein Products
December 2014 Wiley Online Library: Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer\'s disease | Beta Amyloid Products
December 2014 Wiley Online Library: CSF beta-amyloid 1–42 – what are we measuring in Alzheimer\'s disease? | Beta Amyloid Products
December 2014 Taylor Francis Online: Role of amyloid β in the induction of lipolysis and secretion of adipokines from human adipose tissue | Beta Amyloid Products
November 2014 ACS Publications: A Synchrotron-based Hydroxyl Radical Footprinting Analysis of Amyloid Fibrils and Pre-fibrillar Intermediates with Residue-specific Resolution | Beta Amyloid Products
November 2014 Neurobiol Aging.: Resting microglia react to Aβ42 fibrils but do not detect oligomers or oligomer-induced neuronal damage. | Beta Amyloid Products
November 2014 Springer Link: β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1 | Beta Amyloid Products
November 2014 Acta Neurolpathol.: Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease. | Synuclein Products
November 2014 Science Direct: Increased plasma oligomeric alpha-synuclein in patients with lysosomal storage diseases | Synuclein Products
November 2014 ACS Publications: Capping of Aβ42 oligomers by small molecule inhibitors | Beta Amyloid Products
October 2014 The Journal of Biological Chemistry: The Spleen Tyrosine Kinase (syk) Regulates Alzheimer\'s Aβ Production and Tau Hyperphosphorylation | Beta Amyloid Products
October 2014 Annals of Neurology: Amyloid-β efflux from the central nervous system into the plasma | Beta Amyloid Products
October 2014 Nature: A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury | Other Products
October 2014 Science Direct: In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes | Beta Amyloid Products
September 2014 The Journal of Biological Chemistry: Molecular Mechanisms of Alzheimer′s Disease Protection by the A673T Allele of Amyloid Precursor Protein | Beta Amyloid Products
September 2014 Front Aging Neurosci.: Reciprocal modulation of Aβ42 aggregation by copper and homocysteine. | Beta Amyloid Products
August 2014 Front Aging Neurosci.: Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice. | Tau Products
August 2014 Wiley Online Library: Fibrillar β‐amyloid 1‐42 alters cytokine secretion, cholinergic signalling and neuronal differentiation | Beta Amyloid Products
August 2014 The Journal of Biological Chemistry: Aβ-specific DARPins as a novel class of potential therapeutics for Alzheimer’s disease | Beta Amyloid Products
July 2014 Science Direct: Nanoliposomes presenting on surface a cis-glycofused benzopyran compound display binding affinity and aggregation inhibition ability towards Amyloid β1-42 peptide | Beta Amyloid Products
July 2014 Hindawi: Identification and Preclinical Pharmacology of the -Secretase Modulator BMS-869780 | Beta Amyloid Products
July 2014 Scientific Reports: Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson\'s Disease Brain Tissue by Intact Protein Mass Spectrometry | Synuclein Products
July 2014 ACS Publications: ESEEM Analysis of Multi-Histidine Cu(II)-Coordination in Model Complexes, Peptides, and Amyloid-β | Beta Amyloid Products
July 2014 PLoS One: Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer\'s disease. | Beta Amyloid Products
July 2014 The Journal of Neuroscience: Transgenic Mice Overexpressing Amyloid Precursor Protein Exhibit Early Metabolic Deficits and a Pathologically Low Leptin State Associated with Hypothalamic Dys | Beta Amyloid Products
July 2014 Wiley Online Library: Intracellular selection of peptide inhibitors that target disulphide-bridged Aβ42 oligomers | Beta Amyloid Products
July 2014 NIH.gov: Characterizing Methyl-Bearing Side Chain Contacts and Dynamics Mediating Amyloid-b Protofibril Interactions Using 13C methyl-DEST and Lifetime Line Broadening | Beta Amyloid Products
July 2014 Science Direct: The use of nanopore analysis for discovering drugs which bind to α-synuclein for treatment of Parkinson\'s disease | Synuclein Products
July 2014 Wiley Online Library: A distinct subfraction of Aβ is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer\'s disease brain | Beta Amyloid Products
June 2014 Curr Alzheimer Res.: Is Formaldehyde the Missing Link in AD Pathology? The Differential Aggregation of Amyloid-Beta with APOE Isoforms In Vitro. | Beta Amyloid Products
June 2014 ACS Publications: Multifunctional D2/D3 Agonist D-520 with High in Vivo Efficacy: Modulator of Toxicity of Alpha-Synuclein Aggregates | Synuclein Products
June 2014 Science Direct: The amyloid-β degradation pattern in plasma—A possible tool for clinical trials in Alzheimer\'s disease | Beta Amyloid Products
June 2014 Science Direct: A novel cell line from spontaneously immortalized murine microglia | Beta Amyloid Products
June 2014 Metapress: Modulation of Amyloid-β Protein Precursor Expression by HspB1 | Beta Amyloid Products
May 2014 Oxford Journals: Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain | Beta Amyloid Products
May 2014 JCI: The Journal of Clinical Investigation: Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation | Synuclein Products
May 2014 The Journal of Physical Chemistry: Pyroglutamylated Amyloid-β Peptide Reverses Cross β-Sheets by a Prion-Like Mechanism | Beta Amyloid Products
May 2014 pfizerpro.com: Activity of Pramlintide, Rat and Human Amylin but not ABeta 1–42 at Human Amylin Receptors | Beta Amyloid Products
May 2014 Karolinska Institutet: Regenerating the Brain: Stem Cell Differentiation and Cholinergic Dysfunction in Alzheimer Disease | Beta Amyloid Products
May 2014 Science Direct: The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death | Beta Amyloid Products
May 2014 Springer Link: Qualification and application of a liquid chromatography–tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction | Beta Amyloid Products
April 2014 Science Direct: Testing synthetic amyloid-β aggregation inhibitor using single molecule atomic force spectroscopy | Beta Amyloid Products
April 2014 PLOS One: Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells | Synuclein Products
April 2014 FEBS Journal: Resistance of naturally secreted -synuclein to proteolysis | Synuclein Products
April 2014 The Journal of Neuroscience: Suppression of Alzheimer-Associated Inflammation by Microglial Prostaglandin-E2 EP4 Receptor Signaling | Beta Amyloid Products
April 2014 FEBS Journal: Cu(II) and dopamine bind to α-Synuclein and cause large conformational changes | Synuclein Products
April 2014 Science Direct: Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands | Beta Amyloid Products
April 2014 Clinical Chemistry: Quantification of Tau in Cerebrospinal Fluid by Immunoaffinity Enrichment and Tandem Mass Spectrometry | Beta Amyloid Products
March 2014 J Alzheimers Dis.: Modulation of Neuronal Nicotinic Receptor by Quinolizidine Alkaloids Causes Neuroprotection on a Cellular Alzheimer Model. | Beta Amyloid Products
March 2014 Neurobiol Aging.: Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer\'s disease. | Beta Amyloid Products
March 2014 PLOS One: Extracellular Proteolysis of Apolipoprotein E (apoE) by Secreted Serine Neuronal Protease | Beta Amyloid Products
March 2014 The Journal of Biological Chemistry: β-Amyloid Fibrils in Alzheimer Disease Are Not Inert When Bound to Copper Ions but Can Degrade Hydrogen Peroxide and Generate Reactive Oxygen Species | Beta Amyloid Products
March 2014 IOS Press: Synergistic Inhibition of Synaptic Signaling in Cortical Cultures by Subcytotoxic Levels of Oligomerized Amyloid-β and Iron: Alleviation by Zinc | Beta Amyloid Products
March 2014 Metapress: Methylglyoxal Produced by Amyloid-β Peptide-Induced Nitrotyrosination of Triosephosphate Isomerase Triggers Neuronal Death in Alzheimer\'s Disease | Beta Amyloid Products
March 2014 ACS Publications: Retro-inversal of Intracellular Selected β-Amyloid-Interacting Peptides: Implications for a Novel Alzheimer’s Disease Treatment | Beta Amyloid Products
March 2014 IOS Press: Adenosine Triphosphate (ATP) Reduces Amyloid-β Protein Misfolding in vitro | Beta Amyloid Products
March 2014 Science Direct: A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of Aβ | Beta Amyloid Products
March 2014 Science Direct: Pituitary adenylate cyclase-activating polypeptide protects against β-amyloid toxicity | Beta Amyloid Products
March 2014 Biopolymers: Improved chemical synthesis of hydrophobic Aβ peptides using addition of C-terminal lysines later removed by carboxypeptidase B | Beta Amyloid Products
March 2014 Brain Pathology: Reduced Vascular Endothelial Growth Factor and Capillary Density in the Occipital Cortex in Dementia with Lewy Bodies | Beta Amyloid Products
February 2014 Scientific Reports: Ultrasonic force microscopy for nanomechanical characterization of early and late-stage amyloid-β peptide aggregation | Beta Amyloid Products
February 2014 Neurobiol Dis.: Microglial derived tumor necrosis factor-α drives Alzheimer\'s disease-related neuronal cell cycle events | Beta Amyloid Products
February 2014 DOI 10.1007/s00401-014-1256-4: Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials | Synuclein Products
February 2014 DOI: 10.1111/bpa.12130: Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies | Synuclein Products
February 2014 The Journal of Biological Chemistry: Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer | Synuclein Products
February 2014 PLOS One: Comparable Autoantibody Serum Levels against Amyloid- and Inflammation-Associated Proteins in Parkinson’s Disease Patients and Controls | Beta Amyloid Products
February 2014 PLoS ONE: Comparable Autoantibody Serum Levels against Amyloid- and Inflammation-Associated Proteins in Parkinson’s Disease Patients and Controls | Synuclein Products
February 2014 Neuropsychopharmacology: 7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease. | Beta Amyloid Products
January 2014 Diva-Portal: Interaction studies of luminescent conjugatedoligothiophenes with aggregated Amyloid β | Beta Amyloid Products
January 2014 J Vasc Res.: Amyloid-β Increases Metallo- and Cysteine Protease Activities in Human Macrophages | Beta Amyloid Products
January 2014 Invest. Ophthalmol. Vis. Sci.: Development of allele specific gene silencing siRNAs for TGFBI Arg124Cys in Lattice Corneal Dystrophy Type I | Beta Amyloid Products
January 2014 Cambridge University Press: Novel 5-aryloxypyrimidine SEN1576 as a candidate for the treatment of Alzheimer\'s disease | Beta Amyloid Products
January 2014 Nature.com: Zinc depletion regulates the processing and secretion of IL-1β | Beta Amyloid Products
January 2014 ACS Publications: Bexarotene Blocks Calcium-Permeable Ion Channels Formed by Neurotoxic Alzheimer’s β-Amyloid Peptides | Beta Amyloid Products
January 2014 Wiley Online Library: Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro | Beta Amyloid Products
December 2013 Science Direct: Immunogenicity of epitope vaccines targeting different B cell antigenic determinants of human α-synuclein: Feasibility study | Synuclein Products
December 2013 Loyola eCommons: Alpha-Synuclein Aggregates Activate the Nlrp3Inflammasome Following Vesicle Rupture | Synuclein Products
November 2013 IOS Press: In vitro Evidence that an Aqueous Extract of Centella asiatica Modulates α-Synuclein Aggregation Dynamics | Synuclein Products
September 2013 Anal Biochem.: Amyloid-beta isoform metabolism quantitation by stable isotope-labeled kinetics. | Beta Amyloid Products
August 2013 Elsevier B.V.: Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro | Synuclein Products
August 2013 Int Immunopharmacol.: Intravenous immunoglobulin products contain specific antibodies to recombinant human tau protein. | Tau Products
April 2013 PLOS One: Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis | Synuclein Products
April 2013 Current Enzyme Inhibition: Trisubstituted Phenolic Compounds as Inhibitors of Acetylcholinesterase and Amyloid Beta Aggregate Formation. | Beta Amyloid Products
March 2013 J Neurochem.: Inflammation induces multinucleation of Microglia via PKC inhibition of cytokinesis, generating highly phagocytic multinucleated giant cells | Synuclein Products
February 2013 Experimental Neurology: Changes in Properties of Serine 129 Phosphorylated α-Synuclein with Progression of Lewy Type Histopathology in Human Brains | Synuclein Products
February 2013 J Alzheimers Dis.: Rapid, Reversible Impairment of Synaptic Signaling in Cultured Cortical Neurons by Exogenously-Applied Amyloid-β. | Beta Amyloid Products
February 2013 Bioanalysis.: Capillary microsampling and analysis of 4-µl blood, plasma and serum samples to determine human α-synuclein elimination rate in mice. | Synuclein Products
February 2013 J. Peptide Sci: Critique of the use of fluorescence-based reporters in Escherichia coli as a screening tool for the identification of peptide inhibitors of Aβ42 aggregation | Synuclein Products
February 2013 J Alzheimers Dis.: Ibuprofen Inhibits the Synaptic Failure Induced by the Amyloid-β Peptide in Hippocampal Neurons. | Beta Amyloid Products
January 2013 Methods Mol Biol.: Evaluating Amyloid Beta (Aβ) 1-40 Degradation by Capillary Electrophoresis. | Beta Amyloid Products
January 2013 Molecular Genetics and Metabolism: Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity. | Synuclein Products
December 2012 Angew Chem Int Ed Engl.: Mechanism of Fibrillation Inhibition of Amyloid Peptides by Inorganic Nanoparticles Reveal Functional Similarities with Proteins. | Beta Amyloid Products
November 2012 J. Phys. Chem.: Side-Chain Dynamics Reveals Transient Association of Aβ1–40 Monomers with Amyloid Fibers. | Beta Amyloid Products
September 2012 J Biol Chem.: https://www.ncbi.nlm.nih.gov/pubmed/22843695 | Synuclein Products
September 2012 Int Immunopharmacol: Effects of intravenous immunoglobulin on alpha synuclein aggregation and neurotoxicity | Synuclein Products
August 2012 Journal of Neurochemistry: Development and assessment of sensitive immuno‐PCR assays for the quantification of cerebrospinal fluid three‐ and four‐repeat tau isoforms in tauopathies. | Tau Products
July 2012 Journal of Alzheimer\'s disease: JAD: Probing and Trapping a Sensitive Conformation: Amyloid-β Fibrils, Oligomers, and Dimers. | Beta Amyloid Products
July 2012 Journal of Alzheimer\'s Disease: Lowered Serum Amyloid-β1-42 Autoantibodies in Individuals with Lifetime Depression | Synuclein Products
July 2012 FEBS Letters: Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis | Synuclein Products
April 2012 Neurotherapeutics: A Novel \"Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo | Synuclein Products
April 2012 J Pharm Bioallied Sci.: New evidence on α-synuclein and Tau binding to conformation and sequence specific GC* rich DNA: Relevance to neurological disorders | Synuclein Products
March 2012 J. Am. Chem. Soc.: The Crowded Environment of a Reverse Micelle Induces the Formation of β-Strand Seed Structures for Nucleating Amyloid Fibril Formation. https://doi.org/10.1021/ja3004478 | Beta Amyloid Products
February 2012 Acta Neuropathologica: An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology | Synuclein Products
February 2012 Journal of Neurochemistry: α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases. | Synuclein Products
February 2012 Proc. SPIE 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV,: Amyloid diagnostics: probing protein aggregation and conformation with ultrasensitive fluorescence detection. https://doi.org/10.1117/12.909829 | Beta Amyloid Products
February 2012 MAbs.: Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice. | Beta Amyloid Products
January 2012 FEBS Lett.: Effect of N-homocysteinylation on physicochemical and cytotoxic properties of amyloid β-peptide. | Beta Amyloid Products
January 2012 Neuroscience Letters: α-Synuclein potentiates interleukin-1β-induced CXCL10 expression in human A172 astrocytoma cells | Synuclein Products
November 2011 Journal of Neuroinflammation: The acute inflammatory response to intranigral a-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation | Synuclein Products
October 2011 Biochimica et Biophysica Acta (BBA) – Biomembranes: The fusogenic tilted peptide (67–78) of α-synuclein is a cholesterol binding domain | Synuclein Products
August 2011 Journal of Sensors: Quantitative, Label-Free Detection of the Aggregation of α-Synuclein Using Microcantilever Arrays Operated in a Liquid Environment. | Synuclein Products
July 2011 J Biol Chem: Mechanism of Amylin Fibrillization Enhancement by Heparin | Other Products
July 2011 Biophys J: Effect of Zinc Binding on β-Amyloid Structure and Dynamics: Implications for Aβ Aggregation. | Beta Amyloid Products
June 2011 International Journal of Biological Macromolecules: PAMAM G4 dendrimers affect the aggregation of α-synuclein | Synuclein Products
June 2011 Neurochemistry International: Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson\'s disease | Synuclein Products
May 2011 Journal of Molecular Biology: Molecular Basis for the Glycosphingolipid-Binding Specificity of α-Synuclein: Key Role of Tyrosine 39 in Membrane Insertion | Synuclein Products
May 2011 PNAS: Site-specific enzymatic polysialylation of therapeutic proteins using bacterial enzymes | Other Products
April 2011 Langmuir: Single Vesicle Observations of the Cardiolipin−Cytochrome c Interaction: Induction of Membrane Morphology Changes | Synuclein Products
April 2011 J Biol Chem.: Role of Matrix Metalloproteinase 3-mediated α-Synuclein Cleavage in Dopaminergic Cell Death | Synuclein Products
April 2011 Protein Pept Lett.: Solution NMR Studies of Aβ Monomer Dynamics. | Beta Amyloid Products
February 2011 PLoS ONE: Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5) | Synuclein Products
January 2011 J Neurosci Methods: A simple magnetic separation method for high-yield isolation of pure primary microglia | Synuclein Products
November 2010 Arch Neurol: SNCA variant associated with Parkinson disease and plasma alpha-synuclein level | Synuclein Products
October 2010 J Am Soc Mass Spectrom: On-line bioaffinity-electrospray mass spectrometry for simultaneous detection, identification, and quantification of protein-ligand interactions | Synuclein Products
October 2010 J Neurosci Methods: Production of a monoclonal antibody, against human α-synuclein, in a subpopulation of C57BL/6J mice, presenting a deletion of the α-synuclein locus | Synuclein Products
September 2010 Clinical & Experimental Immunology: Specific antibodies to soluble alpha-synuclein conformations in intravenous immunoglobulin preparations | Synuclein Products
September 2010 Biophysical Journal: Measurement of the Attachment and Assembly of Small Amyloid-β Oligomers on Live Cell Membranes at Physiological Concentrations Using Single-Molecule Tools. | Beta Amyloid Products
July 2010 J Immunol: Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1 | Synuclein Products
June 2010 Proteomics: Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by alpha-synuclein | Synuclein Products
March 2010 Brain: DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease | Synuclein Products
March 2010 PLoS One: The Alzheimer\'s Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide. | Beta Amyloid Products
January 2010 Journal of Alzheimer\'s Disease: Tau Phosphorylated at Tyrosine 394 is Found in Alzheimer\'s Disease Tangles and can be a Product of the Abl-Related Kinase, Arg | Tau Products
November 2009 Pharmacol Rep: Effect of N-methyl-D-aspartate (NMDA) receptor antagonists on alpha-synuclein-evoked neuronal nitric oxide synthase activation in the rat brain | Synuclein Products
October 2009 Int J Biochem Cell Biol: Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells | Synuclein Products
September 2009 Toxicol Sci: Potential role of alpha-synuclein and metallothionein in lead-induced inclusion body formation | Synuclein Products
June 2009 Int J Mass Spectrom: Charge State Dependent Fragmentation of Gaseous alpha-Synuclein Cations via Ion Trap and Beam-Type Collisional Activation | Synuclein Products
May 2009 Appl Spectrosc: Probing water and biomolecules at the air-water interface with a broad bandwidth vibrational sum frequency generation spectrometer from 3800 to 900 cm(-1) | Synuclein Products
May 2009 J Biol Chem: Dynamic alpha-helix structure of micelle-bound human amylin | Other Products
January 2009 Folia Neuropathol: Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway. | Synuclein Products
January 2009 Biochem Biophys Res Commun: The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers | Synuclein Products
January 2009 Methods Mol Biol: Mass spectrometry detection and characterization of noncovalent protein complexes | Synuclein Products
November 2008 Journal of the American Society for Mass Spectrometry: Protein–Metal Interactions of Calmodulin and α-Synuclein Monitored by Selective Noncovalent Adduct Protein Probing Mass Spectrometry | Synuclein Products
September 2008 The Journal of Physical Chemistry B: Spermine Binding to Parkinson’s Protein α-Synuclein and Its Disease-related A30P and A53T Mutants | Synuclein Products
September 2008 Moleculalr Membrane Biology: The effect of α-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron mircroscopy | Synuclein Products
July 2008 Journal of Virology: Length Requirements for Membrane Fusion of Influenza Virus Hemagglutinin Peptide Linkers to Transmembrane or Fusion Peptide Domains {triangledown} | Synuclein Products
June 2008 Vaccine: HIV-1 envelope glycoprotein-mediated fusion and pathogenesis: Implications for therapy and vaccine developmentstar | Synuclein Products
June 2008 Journal of the American Chemical Society: Design of an N-Methylated Peptide Inhibitor of α-Synuclein Aggregation Guided by Solid-State NMR | Synuclein Products
May 2008 Neuroscience Letters: Cleavage of normal and pathological forms of α-synuclein by neurosin in vitro | Synuclein Products
April 2008 PNAS: Stabilization of a β-hairpin in monomeric Alzheimer\'s amyloid-β peptide inhibits amyloid formation | Beta Amyloid Products
April 2008 Journal of the Cellular and Molecular Life Sciences: Mitochondrial association of alpha-synuclein causes oxidative stress | Synuclein Products
February 2008 Journal of Neuroscience Methods: A more efficient enzyme-linked immunosorbent assay for measurement of α-synuclein in cerebrospinal fluid | Synuclein Products
January 2008 The International Journal of Biochemistry & Cell Biology: Interactive sequences in the molecular chaperone, human αB crystallin modulate the fibrillation of amyloidogenic proteins | Synuclein Products
January 2008 Virology: Analysis of residues near the fusion peptide in the influenza hemagglutinin structure for roles in triggering membrane fusion | Synuclein Products
January 2008 J. Proteome Res: Local and Nonlocal Environments around Cis Peptides | Synuclein Products
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