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Salirasib

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Displaces active Ras protein from the plasma membrane inhibiting its activity, IC50=10-15 µM1. Enhances autophagy in a variety of cell lines2. Protects against HIV-1-induced accumulation of Aβ in human brain microvascular endothelial cells3. Displays antiinflammatory activity, inhibiting the release of PGD2 and TNFα from mast cells4.

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1. R Haklai et al. Biochemistry 1998 37:13062. E Schmuckler et al. Oncotarget 2013 4:1453. IE Andras et al. Biochem. Biophys. Res. Commun. 2012 421:1774. A Mor et al. Inflammation 2011 34:314 2020 rPeptide ph: 866.753.0747 | fax: 678.753.0746 | sales@rpeptide.com

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