These preformed fibrils of tau-441 may be used as a model for the pathogenic form of tau in numerous tauopathies. Sourced from E. coli, tau-441 fibrils were prepared and confirmed by thioflavin assay and electron microscopy, which shows an average size ranging from 50nm-200nm. Applications of this product range from in vitro studies on fibril formation and stability 1 to in vivo studies on cellular uptake, cell viability and pathway activation 2. This product is also suitable for use in mouse models for studies involving memory, neuronal health, or seeding and prion like spreading 3. Recent assessment of the Amyloid hypothesis has led to the realization that wildtype tau is accumulated in various tauopathies including Alzheimer’s disease, Pick’s disease, and progressive supranuclear palsy among others. Applied to either in vivo or in vitro experiments, these fibrils may be utilized to investigate the mechanism of various tauopathies.
用产品只提供给进一步的科研使用，不可应用于治疗等其他方面。 rPeptide是设在雅典，美国佐治亚州的一家生物技术公司，是一种在阿尔茨海默氏症和帕金森氏病的研究提供研究产品（重组多肽和蛋白质，抗体，试剂）市场的*。rPeptide还提供定制服务的范围从分子生物学，蛋白表达和纯化，13C和15N的多肽和蛋白质的统一标识。 rPeptide有一个专有的平台载体技术，使可溶性肽/蛋白在大肠杆菌中（如淀，β-淀粉样蛋白，瘦素，亲胰岛素）历史上的困难肽/蛋白表达。 商品名称 商品货号 商品品牌 Beta-Amyloid (1-40), Mouse, Rat A-1007-1 rPeptide Beta-Amyloid (1-40), Starter Kit A-1150-1 rPeptide Beta-Amyloid (1-40), Starter Kit A-1150-2 rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl A-1156-1 rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl A-1156-2 rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP A-1153-1 rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP A-1153-2 rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH A-1155-1 rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH A-1155-2 rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA A-1001-1 rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA A-1001-2 rPeptide Beta-Amyloid (1-40, D23N) A-1013-1 rPeptide Beta-Amyloid (1-40, D23N) A-1013-2 rPeptide Beta-Amyloid (1-40, F4W) A-1011-1 rPeptide Beta-Amyloid (1-40, F4W) A-1011-2 rPeptide
