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ABT737

Chemical

C42H45ClN6O5S2

813.4

852808-04-9

≥95%

Solid.

Soluble in DMSO. Slightly soluble (

Manufactured by SynKinase.

Target: Bcl-2 | Kinase Group: PPI | Substrate: N/AClick here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet.

HPLNQCPCUACXLM-PGUFJCEWSA-N

AMBIENT

+4°C

-20°C

Stable for at least 2 years after receipt when stored at -20°C.

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ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 exhibits single-agent-mechanism-based killing of cells from lymphoma and small-cell lung carcinoma lines, as well as primary patient-derived cells, and in animal models, ABT-737 improves survival, causes regression of established tumors, and produces cures in a high percentage of the mice. ABT-737 binds to Bcl-2, Bcl-xL and Bcl-w with very high affinities (Ki Product References

An inhibitor of Bcl-2 family proteins induces regression of solid tumours: T. Oltersdorf, et al.; Nature 435, 677 (2005)

Synthesis and biological activities of new di- and trimeric quinoline derivatives: S. Broch, et al.; Bioorg. Med. Chem. 18, 7132 (2010)

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL: B.E. Sleebs, et al.; J. Med. Chem. 56, 5514 (2013)

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