exosome detectionSBI/ExoAb Antibody Kit (CD9, CD63, CD81, Hsp70 antibodies, rabbit anti-human) with goat anti-rabbit HRP secondary antibo System Biosciences,简称SBI，美国加州湾区新成立的生技公司，致力于独特、创蚂蚁淘技术之开发，以研发利于基因及蛋白质功能鉴定、研究之崭新方法和工具为宗旨。 现阶段研发重心为RNA干扰（RNAi）研究之相关工具。 System Biosciences (SBI) 致力于开发独特、革新的技术，为客户研究蛋白组学和基因组学功能提供研究工具。SBI 是专业的慢病毒产品公司，提供基于慢病毒的所有相关产� Overview:

Confirmexosomeisolationwithconfidence

Whenyou’rereadytoconfirmthatyou’veisolatedexosomes,stickwiththeexosomeexpertsatSBI.OurExoAbAntibodyKitincludesantibodiestofourofthemostcommonlyusedexosomeMarkers—CD9,CD63,CD81,andHPS70.Theseareallpolyclonalrabbitantibodiesthatrecognizethehuman,mouse,andratformsoftheprotein,andareagreatchoiceforgeneralexosomedetection(ifyouhaveanyquestionsaboutthebestantibodiestouseforyourexosomeproject,we’rereadytohelp!Justemailusattech@systembio.com).And,likeallofourantibodies,theantibodiesinthiskit,includingthegoatanti-rabbitHRPsecondaryantibodies,arerigorouslyvalidatedforexosomedetectionviaWesternblotting.RigorouslyvalidatedHand-pickedselectionExpertexosomesupport

Choosetherightantibodyforyourexosomedetectionneeds

Cat.#AntibodytoNotesLinktoExoCartaentryforthehumanproteinGeneralexosomemarkersEXOAB-CD9A-1CD9TetraspaninExoCarta_928EXOAB-CD63A-1CD63TetraspaninExoCarta_967EXOAB-CD81A-1CD81TetraspaninExoCarta_93185EXOAB-Hsp70A-1HSP70ExoCarta_3303,ExoCarta_3304,ExoCarta_3306,ExoCarta_3308,ExoCarta3310,ExoCarta_3311EXOAB-ALIX-1ALIXProgrammedcelldeath6interactingprotein(PDCD6IP)ExoCarta_10015EXOAB-ANXA5-1ANXA5-1AnnexinA5ExoCarta_308EXOAB-TSG101-1TSG101Tumorsusceptibilitygene101ExoCarta_7251EXOAB-FLOT1-1FLOT-1Flotillin-1ExoCarta_10211Tissue-specificexosomemarkersEXOAB-CXCR4-1CXCR4SpecificforB-cells,T-cells,andplateletsExoCarta_7852EXOAB-EPCAM1-1EpCamSpecificforcancer-derivedexosomesExoCarta_4072EXOAB-VMTN-1VimentinSpecificformesenchymalstemcellsExoCarta_7431

Citations:Hsu,YL,etal.(2017)Hypoxiclungcancer-secretedexosomalmiR-23aincreasedangiogenesisandvascularpermeABIlitybytargetingprolylhydroxylaseandtightjunctionproteinZO-1.Oncogene.2017Apr24;.PMID:28436951Hao,YX,etal.(2017)KRASandBRAFmutationsinserumexosomesfrompatientswithcolorectalcancerinaChinesepopulation.OncolLett.2017May1;13(5):3608-3616.PMID:28521461Joy,M,etal.(2017)TheMyocardin-relatedtranscriptionfactorMKLco-regulatesthecellularlevelsoftwoprofilinisoforms.J.Biol.Chem..2017May25;.PMID:28546428LIN,F,etal.(2017)Effectsofesophagealcancercell-derivedexosomesoncancercellmigrationandinvasionanditsmechanismresearch.MedicalJournalofChinesePeople\"sLiberationArmy.2017Apr1;42(1):307-.Link:MedicalJournalofChinesePeople\"sLiberationArmyYoon,S,etal.(2017)MLKL,theProteinthatMediatesNecroptosis,AlsoRegulatesEndosomalTraffickingandExtracellularVesicleGeneration.Immunity.2017Jun22;.PMID:28666573Dickman,CT,etal.(2017)SelectiveextracellularvesicleexclusionofmiR-142-3pbyoralcancercellspromotesbothinternalandextracellularmalignantphenotypes.Oncotarget.2017Feb28;8(9):15252-15266.PMID:28146434Koh,YQ,etal.(2016)Characterizationofexosomalreleaseinbovineendometrialintercaruncularstromalcells.Reprod.Biol.Endocrinol..2016Nov9;14(1):78.PMID:27829441McNicholas,K,etal.(2016)Albuminuriaisnotassociatedwithelevatedurinaryvesicleconcentrationbutcanconfoundnanoparticletrackinganalysis.Nephrology(Carlton).2016Aug6;.PMID:27496221Fischer,S,etal.(2016)IndicationofHorizontalDNAGeneTransferbyExtracellularVesicles.PLoSONE.2016Sep29;11(9):e0163665.PMID:27684368Wen,S,etal.(2016)Mesenchymalstromalcell-derivedextracellularvesiclesrescuerADIationdamagetomurinemarrowhematopoieticcells.Leukemia.2016Nov1;30(11):2221-2231.PMID:27150009Spencer,B,etal.(2016)α-SynucleininterfereswiththeESCRT-IIIcomplexcontributingtothepathogenesisofLewybodydisease.Hum.Mol.Genet..2016Mar15;25(6):1100-15.PMID:26740557Silvers,CR,etal.(2016)Identificationofextracellularvesicle-borneperiostinasafeatureofmuscle-invasivebladdercancer.Oncotarget.2016Apr26;7(17):23335-45.PMID:26981774Kouwaki,T,etal.(2016)ExtracellularVesiclesIncludingExosomesRegulateInnateImmuneResponsestoHepatitisBVirusInfection.FrontImmunol.2016Sep16;7:335.PMID:27630638Diaz-Hidalgo,L,etal.(2016)Transglutaminasetype2-dependentselectiverecruitmentofproteinsintoexosomesunderstressfulcellularconditions.Biochim.Biophys.Acta.2016Aug1;1863(8):2084-92.PMID:27169926Endo-Munoz,L,etal.(2015)ProgressionofOsteosarcomafromaNon-MetastatictoaMetastaticPhenotypeIsCausallyAssociatedwithActivationofanAutocrineandParacrineuPAAxis.PLoSONE.2015Aug31;10(8):e0133592.PMID:26317203Lee,JC,etal.(2015)Papillarythyroidcancer-derivedexosomescontainmiRNA-146bandmiRNA-222.J.Surg.Res..2015Jun1;196(1):39-48.PMID:25819770Luo,X,etal.(2015)ExosomesareunlikelyinvolvedinintercellularNeftransfer.PLoSONE.2015Apr29;10(4):e0124436.PMID:25919665Kanada,M,etal.(2015)Differentialfatesofbiomoleculesdeliveredtotargetcellsviaextracellularvesicles.Proc.Natl.Acad.Sci.U.S.A..2015Mar24;112(12):E1433-42.PMID:25713383Amorim,M,etal.(2014)Theoverexpressionofasingleoncogene(ERBB2/HER2)alterstheproteomiclandscapeofextracellularvesicles.Proteomics.2014Jun1;14(12):1472-9.PMID:24733759 System Biosciences,简称SBI，美国加州湾区新成立的生技公司，致力于独特、创蚂蚁淘技术之开发，以研发利于基因及蛋白质功能鉴定、研究之崭新方法和工具为宗旨。 现阶段研发重心为RNA干扰（RNAi）研究之相关工具。 System Biosciences (SBI) 致力于开发独特、革新的技术，为客户研究蛋白组学和基因组学功能提供研究工具。SBI 是专业的慢病毒产品公司，提供基于慢病毒的所有相关产品、质粒、试剂盒及相关配套试剂和慢病毒延伸产品如IPS细胞多功能性诱导试剂盒和RNAi筛选文库。 SBI focuses on developing unique, innovative technologies that provide researchers with the tools to investigate and understand genomic and proteomic function. Our mission is to provide tools for the genome-wide analysis of the mechanisms that regulate cellular processes and biological responses. Headquartered in Palo Alto about 30 miles south of San Francisco, SBI is geographically surrounded by highly successful research biotech companies (e.g., Affymetrix, Life Technologies, and Genentech) and some of the premier life science institutes in the world, including Stanford and the University of California, San Francisco. As a small private biotechnology company, SBI capitalizes on a rich network of consultants and colleagues and continually collaborates to accelerate its development of innovative and novel applications. Currently, SBI has partnerships with over thirty scientists from several institutes.System Biosciences (SBI) consists of a highly motivated team committed to realizing the potential of its mission to develop and bring to market unique and innovative technology to investigate and understand genomic and proteomic function. Possessing a diverse range of experience and knowledge, SBI\'s management and staff bring the skills, talent, and interest needed to support the company\'s continuing rapid growth. A strong and proven background in creative research and product development with proficiency in genetic analysis, microarray technology, and cell biology Extensive business development and management experience A keen understanding of the needs of life scientists Expertise in developing, marketing, and supporting consistent, high-quality research products A clear focus on the need to build and maintain lasting customer relationships through support, service, and close customer interaction

苏州蚂蚁淘生物科技有限公司是一家创新型高科技生物公司，以常规生物学实验外包与生物学试剂为基础，放眼于生命科学领域的前沿技术服务，公司技术骨干有着多年的生物学科研背景，毕业于国内外名牌大学，并且有着丰富的项目经验，了解国内外科研行情，我公司力求为每一个客户提专业、针对性的实验方案。我公司以技术服务为支点，和国内外多家生物试剂公司有着密切的业务往来.公司特色技术服务包括：抗体药物研发、噬菌体抗体库、蛋白表达与传化、抗体制备、高通量测序、组学研究、生物信息学分析与方法建立、基础分子生物学技术外包、化学中间体合成、原料药物研发、论文编写等。我公司秉承”诚信做人，认真做事，服务至上\"，希望用我们的专业知识和项目经验为国内科研客户解决科研问题，祝您科研之路畅通无阻！

System Biosciences (SBI) 致力于开发独特、革新的技术，为客户研究蛋白组学和基因组学功能提供研究工具。SBI 也是专业的慢病毒产品公司，提供基于慢病毒的所有相关产品，如质粒、试剂盒及其它配套试剂；以及慢病毒延伸产品，如IPS细胞多功能性诱导试剂盒和RNAi筛选文库等。 （一）：14天----从构建到包装出毒----革命性的慢病毒包装系统；

包括分别用于表达慢病毒、shRNA、microRNA的表达系统，含多种报告基因及抗性基因可选，其中用于表达microRNA的载体有富集microRNA及用于检测信号通路的载体可选。包装系统中配套有无酶连接体系，可在连接效率不变的情况下将载体构建时间缩短，简化实验步骤（如下图）。上图：病毒浓缩试剂：仅需2小时操作时间；可达10到100倍浓缩效果。（二）：干细胞(iPSC)最新进展（三）：microRNA技术，如何寻找新的microRNA，及功能鉴定• 前期用于筛选的microRNA表达谱芯片：包括与癌症、 干细胞分化相关；人、小鼠以 及大鼠全基因中所有microRNA表达谱芯片。• microRNA的逆转录及目标microRNA定量试剂盒。• microRNA扩增试剂盒。• 对已知功能的microRNA的过表达以及敲除microRNA表达的研究。（四）：RNAi干扰文库的应用包括人的RNAi文库、小鼠的RNAi文库、信号通路的RNAi文库三种信号通路RNAi文库包括 • Apoptosis （细胞凋亡通路） • Kinase （激酶通路） • Phosphatase（磷酸酶通路）用户使用产品发表文章（部分）Sooryanarayana Varambally, Qi Cao, etc. Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer .Science 322, 1695 (2008);RavinR, Hoeppner DJ, etc. Potency and fate specification in CNS stem cell popolations in viro. Cell Stem Cell. 2008 Dec 4;3(6):670-80Parikh H., Carlsson E., Chutkow W. A., etc. TXNIP Regulates Peripheral Glucose Metabolism in Humans. Plos Med. 4 (5): e158, 2007. (PDF) »Shaftel S. S., Kyrkanides S., Olschowka J. A., Miller J. H., Johnson R. E., and O’Banion M. K. Sustained hippocampal IL-1ß overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J. Clin. Invest. 117:1595-1604, 2007.Si Z., Vandegraaff N., O”hUigin C., Song B., Yuan W., Xu C., Perron M., Li X., Marasco W. A., Engelman A., Dean M. and Sodroski J. Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection. PNAS, 103 (19): 7454-7459, 2006.

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