Exosome是由多种活细胞分泌的50-100nm的膜性小囊泡，来源于晚期核内体（也成为多囊泡体）的囊泡，是由细胞内多泡体（MVBs）出芽形成，再与细胞膜融合后释放到细胞外基质中。几乎所有类型的细胞都能分泌，广泛存在于各种体液中。不同细胞来源的Exosome所含有的具体成分不尽相同，根据分泌的细胞类型不同，在血液、尿液、羊水、恶性肿瘤、腹水等动物体液中的Exosome通常含有特定的miRNA和蛋白质，因此，Exosome为研究潜在的各种bioMarker提供了很好的生物学材料。      Exosome参与调控重要的细胞生理活动，在免疫应答、凋亡、血管生成、炎症反应、凝结过程中的作用均有报道，可以成为多种疾病的早期诊断标记物，也能作为靶向药物的载体进行疾病治疗。作为囊泡的一种，Exosome受到越来越多的关注。2013年诺贝尔奖揭晓，美国、德国3位科学家James E. Rothman, Randy W. Schekman和Thomas C. Sudhof因\"发现细胞内的主要运输系统-囊泡运输的调节机制”，荣获2013年诺贝尔生理学或医学奖。这一奖项的授予，无疑将囊泡的研究推向了新的高潮。 一、Exosome抽提SBI公司研究和开发了一款基于多聚体形式的Exosome提取试剂，能够快速有效地提取及分离血清和肿瘤组织样本中的Exosome囊泡。这些多聚体能够形成类似于网状结构，从而将60-180nm直径的微泡分离出来。其纯度和产量皆优于上述传统方法。（一）基于血清和血浆样本  货号产品规格价格（元）EXOQ5A-1ExoQuickexosome precipitation solution5ml(75T)4203.2EXOQ20A-1ExoQuickexosome precipitation solution20ml(300T)

（二）基于细胞培养上清、组织、尿液样本

13561

货号产品规格价格（元）EXOTC10A-1ExoQuick TC exosome precipitation solution10ml(10T)4189EXOTC50A-1ExoQuick TC exosome precipitation solution50ml(50T)孵育时间样本样本体积ExoQuick TC体积过夜（12小时）尿液5ml1ml4℃过夜（12小时）细胞培养上清5ml货号产品规格价格（元）EXOLP5A-1ExoQuick-LP Lipoprotein PreClear&Exosome Precipitation Kit10T货号产品规格价格（元）TMEXO-1Thrombin Plasma prep for Exosome Precipitation100T6347.4EXOQ5TM-1ExoQuick Plasma prep and Exosome Precipitation Kit75TMarker TypeFunctionsExamplesTetraspaninsExosome formation and secretionCD9, CD63, CD81Targeting/AdhesionExosome maturation and target cell bindingIntegrins, ICAM-1, CD31, CD44Antigen PresentationImmune modulation, anergy and primingMHC I/II, HLA-GMembrane transport and fusionExosome biogenesis, secretion and downstream cell fusion

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• 产品信息

14072

1ml

5751

9471.4

SNAP, Annexins, Rab5b

货号名称规格价格（元）EXOFLOW100A-1CD9 Exo-Flow capture kit (Magnetic streptavidin beads, CD9-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)10 reactions5736.8EXOFLOW150A-1TetraspaninExo-Flow combo capture kit (Magnetic streptavidin beads, CD9, CD63, and CD81-biotin capture antibodies, Wash and Elution Buffers, Exo-FITC stain)10 reactions8718.8EXOFLOW200A-1CD31 Exo-Flow capture kit (Magnetic streptavidin beads, CD31-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)10 reactions5736.8EXOFLOW210A-1CD44 Exo-Flow capture kit (Magnetic streptavidin beads, CD44-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)10 reactions5736.8EXOFLOW300A-1CD63 Exo-Flow capture kit (Magnetic streptavidin beads, CD63-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)10 reactions5736.8EXOFLOW400A-1CD81 Exo-Flow capture kit (Magnetic streptavidin beads, CD81-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)10 reactions5736.8EXOFLOW500A-1Rab5b Exo-Flow capture kit (Magnetic streptavidin beads, Rab5b-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)10 reactions5736.8EXOFLOW600A-1HLA-G Exo-Flow capture kit (Magnetic streptavidin beads, HLA-G-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)10 reactions5736.8EXOFLOW610A-1CD14 Exo-Flow capture kit (Magnetic streptavidin beads, CD14-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)10 reactions5736.8EXOFLOW620A-1CD68 Exo-Flow capture kit (Magnetic streptavidin beads, CD68-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)10 reactions5736.8EXOFLOW630A-1EpCAMExo-Flow capture kit (Magnetic streptavidin beads, EpCAM-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)10 reactions5736.8EXOFLOW650A-1Alpha-2-Macroglobulin (A2M) Exo-Flow capture kit (Magnetic streptavidin beads, A2M-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)10 reactions5736.8EXOFLOW700A-1Exo-Flow Multifunctional Magnetic Stand1 Kit3947.6EXOFLOW800A-1Exo-FITC Exosome FACS stain20 reactions2158.4EXOFLOW810A-1Exo-APC Exosome FACS stain20 reactions2158.4CSFLOWBASICA-1Basic Exo-Flow kit without any coupled antibodies (Uncoupled magnetic streptavidin beads, Wash and Elution Buffers, Exo-FITC stain)100 reactions9869货号产品名称规格价格（元）EXOAB-CD63A-1Anti-CD63 Antibody (rabbit anti-human, mouse, rat, horse) with goat anti-rabbit HRP secondary antibody25 ul1902.8EXOAB-CD81A-1Anti-CD81 Antibody (rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul1902.8EXOAB-CD9A-1Anti-CD9 Antibody (rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul1902.8EXOAB-Hsp70A-1Anti-Hsp70 Antibody (rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul1902.8EXOAB-CETP-1Anti-CETP Antibody (polyclonal rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul1902.8EXOAB-KIT-1ExoAb Antibody Kit (CD9, CD63, CD81, Hsp70 antibodies, rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul each6475.2EXOAB-FLOT1-1Anti-FLOT1 Antibody (rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul1902.8EXOAB-EPCAM1-1Anti-EpCam Antibody (rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul1902.8EXOAB-TSG101-1Anti-TSG101 Antibody (rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul1902.8EXOAB-CXCR4-1Anti-CXCR4 Antibody (rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul1902.8EXOAB-VMTN-1Anti-Vimentin Antibody (rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul1902.8EXOAB-ALIX-1Anti-ALIX Antibody (rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul1902.8EXOAB-ANXA5-1Anti-ANXA5 Antibody (rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody25 ul1902.8Exosome抗体运输与保存：蓝冰运输，收到产品后4℃保存，长期保存可置于-20℃.收到产品后有效期为6个月以上。（二）ELISA定量分析货号产品名称规格价格（元）EXOEL-CD63A-1Exosome ELISA Complete Kit (CD63 detection)96 reactions8378EXOEL-CD81A-1Exosome ELISA Complete Kit (CD81 detection)96 reactions8378EXOEL-CD9A-1Exosome ELISA Complete Kit (CD9 detection)96 reactions8378EXOCET96A-1EXOCET Exosome Quantitation Kit96 reactions5609EXOAB-POS-1Human Exosome lysate positive protein control (10ug/ul)50 ul3436.4EXOEL-BB-20Exosome binding buffer for ELISAs20 ml1902.8

运输与保存：试剂盒由蓝冰运输，4℃保存，其中，ExoELISA蛋白标准品需保存在-20℃，建议蛋白样本分装，以避免反复冻融。有效期为收到产品后6个月。四、Exosome功能研究（一）荧光标记ExosomeSBI新产品Exo-Glow试剂盒，能够荧光标记内源的Exosome RNAs为红色，标记内部Exosome蛋白为绿色，从而达到使用荧光显微镜实时追踪Exosome细胞内相互作用和物质运输。

货号产品名称规格价格EXOR100A-1Exo-Red exosome RNA fluorescent label20 rxns4047EXOG200A-1Exo-Green exosome protein fluorescent label20 rxns4047EXOC300A-1Exo-Red + Exo-Green exosome cargo fluorescent label Combo Pack (10 rxns of each label)20 rxns4615

（二）利用Cyto-Trace让细胞分泌带有荧光的Exosome四次跨膜蛋白CD9、CD63和CD81蛋白为Exosomes常见的生物标记蛋白。通过CD63和CD9 Cyto-Trace质粒，可以让您研究的靶细胞分泌带有绿色或者红色荧光的Exosomes，以便下游功能性运输研究。

货号产品名称规格价格CYTO120-PA-1pCT-CD63-GFP (pCMV, Exosome/Secretory, CD63 Tetraspanin Tag)10ug7540.2CYTO120R-PA-1pCT-CD63-RFP (pCMV, Exosome/Secretory, CD63 Tetraspanin Tag)10 ug7540.2CYTO122-PA-1pCT-CD9-GFP (pCMV, Exosome/Secretory, CD9 Tetraspanin Tag)10 ug7540.2CYTO123-PA-1pCT-CD9-RFP (pCMV, Exosome/Secretory, CD9 Tetraspanin Tag)10 ug7540.2CYTO124-PA-1pCT-CD81-GFP (pCMV, Exosome/Secretory, CD81 Tetraspanin Tag)10 ug7540.2CYTO125-PA-1pCT-CD81-RFP (pCMV, Exosome/Secretory, CD81 Tetraspanin Tag)10 ug7540.2货号产品名称规格价格EXFT10A-1Exo-FectExosome Transfection Kit10 reactions2769EXFT20A-1Exo-FectExosome Transfection Kit20 reactions4970货号产品名称规格价格RA800A-1Complete SeraMirExosome RNA Amplification kit (5ml ExoQuick, 20 exoRNA columns, cDNA synthesis and amplification components)20 reactions10280.8RA800TC-1Complete SeraMirExosome RNA Amplification kit from Media and Urine (10ml ExoQuick-TC, 10 exoRNA columns, cDNA synthesis and amplification components)10 preps7227.8RA806TC-1SeraMirExosome RNA Purification only kit for Media and Urine (10ml ExoQuick-TC and 10 exoRNA columns)10 preps6006.6RA808A-1SeraMirExosome RNA Purification Column kit (20 exoRNA columns)20 preps4189RA810A-1Human SeraMirExosome RNA 384 microRNA qPCR Profiler Assay Set20 profiles14824.8RA820A-1Human Complete SeraMirExosome RNA Amplification and Profiling Kit (contains cat# RA800A-1, RA805A-1, RA810A-1 components)20 profiles14824.8RA820TC-1Human Complete SeraMirExosome RNA Amplification and Profiling Kit for Media and Urine (contains cat# RA800TC-1 with 50ml ExoQuick-TC, RA805A-1 and RA810A-1 components)20 profiles18644.6RA811A-1Mouse SeraMirExosome RNA 384 microRNA qPCR Profiler Assay Set20 profiles5708.4RA821A-1Mouse Complete SeraMirExosome RNA Amplification and Profiling Kit (contains cat# RA800A-1, RA805A-1, RA811A-1 components)20 profiles14824.8RA821TC-1Mouse Complete SeraMirExosome RNA Amplification and Profiling Kit for Media and Urine (contains cat# RA800TC-1 with 50ml ExoQuick-TC, RA805A-1 and RA811A-1 components)20 profiles18644.6RA812A-1Rat SeraMirExosome RNA 384 microRNA qPCR Profiler Assay Set20 profiles5708.4RA822A-1Rat Complete SeraMirExosome RNA Amplification and Profiling Kit (contains cat# RA800A-1, RA805A-1, RA812A-1 components)20 profiles14824.8RA822TC-1Rat Complete SeraMirExosome RNA Amplification and Profiling Kit for Media and Urine (contains cat# RA800A-1, RA805A-1, RA812A-1 and EXOTC50A-1 components) 20 profiles20 profiles18644.6RA805A-1SeraMir Control spike-in Small RNA and qPCR assay100 assays2215.2RA800P-3SeraMir 3-Universal Primer bonus pack (for an additional 10,000 qPCR reactions)1.2 ml1533.6 品牌介绍美国SBI（System Biosciences）公司由前Clontech公司的创始人Dr. Ken Fong所创立。SBI一直致力为生命科学前沿领域提供各种最新的研究工具和产品。System Biosciences (SBI) 致力于开发独特、革新的技术，为客户研究蛋白组学和基因组学功能提供研究工具。SBI又称为\"慢病毒公司”，提供各种基于慢病毒的所有产品，包括慢病毒的包装系统，病毒浓缩液，shRNA和microRNA功能研究的慢病毒载体，文库和高滴度的病毒，同时还提供各种基于慢病毒的延伸产品，在干细胞研究领域提供诸如iPS细胞，高效的iPS诱导系统还有检测iPS细胞分化的实时监测系统。SBI同时秉承Clontech在分子克隆领域的成功经验，推出了一系列的高效克隆工具，如革命性的高效无酶连接系统（Cold-fusion Kit），真正做到了5min连接外源基因到载体。          同时SBI还是一家在全球范围内很有名的服务公司，曾为多家知名企业和科研院所提供各种病毒构建，和干细胞服务等。 上海前尘生物科技有限公司www.qcbio.com   4006-111-883 

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