ABL1BreakApartFISHProbe
TheABL1gene,locatedonchromosome9q34.1,isactivatedbybeingtranslocatedwithintheBCR(breakpointclusterregion)geneonchromosome22.Thet(9;22)translocationispresentin~90%ofchronicmyelogeneousleukemia(CML)cases.Thechromosomalabnormality,t(9;22)(q34;q11.2),involvingtheABL1,BCR,andASS1genes,isobservedin~95%ofCML,~20%ofcasesofadultacutelymphoblasticleukemia(ALL),~4%ofcasesofchildhoodALL,and~3%ofacutemyeloidleukemia(AML).
OurABL1BreakApartFISHProbecanbeusedtodetectarearrangementoftheABL1gene.Theprobecomeslabeledingreenandorange,andyoumayalsochoosetocustomizetheprobetomeetyourneeds.
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