货号: | 10007779 |
保存条件: | -20 |
供应商: | Neobioscience |
规格: | .1 mg |
The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals.{8344,8672} The most studied InsP, Ins(1,4,5)P3, more commonly referred to as IP3, is a second messenger produced in cells by PLC-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.{2429,5714} Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.{5714,4096} Ins(2,4,5)P3 is a metabolically stable analog of Ins(1,4,5)P3 that is commonly used to study Ca2+ signaling pathways. Ins(2,4,5)P3 acts as a partial agonist at rat hepatic IP3 receptors, exhibiting 65% of the maximal Ca2+ response obtained with Ins(1,4,5)P3.{13732} 温馨提示:不可用于临床治疗。
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