H3K79me1MouseMonoclonalAntibody
CatalogNo:A90001Species:Mouse
Concentration:100ug/100ulClonality:MouseIgG1
Applications:WB1:500-1:2000Reactivity:Human,Mouse,Rat
Detectedband(bywestern)molecularweight:15kD
Alt.Names
H3histoneantibody,HIST1H3Aantibody,Histonecluster1,H3aantibody
Specificity:
TheHistoneH3(monomethylK79)mousemonoclonalantibodycanrecognizeendogenous
HistoneH3(monomethylK79)proteins.
Immunogen:
MousemonoclonalantibodyispreparedbyimmunizingsyntheticpeptidecoupledtoKLH.
StorageConditionandBuffer:
Storeat-20°C.Stableforoneyearfromthedateofshipment.
1mg/mlinPBS,pH7.4,containing0.02%sodiumazideand50%glycerol
H3K79methylationisoneofthegeneactivationMarkers.DOT1LmethyltransferaseusuallyinvolvesinH3K79methylation,playingessentialrolesinembryonicdevelopment,hematopoiesis,cardiacfunctionandthedevelopmentofleukemia.
TodetectmarkerH3K79methylationstatus,youcanalsopickfromourH3K79polyclonalantibodyseries.
H3K79me1_Mouse_Monoclonal_Antibody.pdf
SDS_H3K79me1_Mouse_Monoclonal_Antibody.pdf
References:
1.RobertACopeland.Proteinmethyltransferasesincancer.(2013)AACRAnnualMeeting.
2.RoyMPollock.PreclinicalCharacterizationofaPotent,SelectiveInhibitoroftheProteinMethyltransferaseDOT1LforUseintheTreatmentofMLL-RearrangedLeukemia.(2012)54thASHAnnualMeetingandExposition.
Forresearchuseonly.Notforhumanuse.