Molecular Weight: | 484.94 |
Formula: | C18H19F3N2O4S2.HCl |
Purity: | ≥98% |
CAS#: | 423148-78-1 |
Solubility: | DMSO up to 100 mM |
Chemical Name: | 5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride |
Storage: | Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year. |
Biological Activity:
WAY-316606 is a novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) with an IC50~ 0.65 μM. It prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. WAY-316606 can increase total bone area in a murine calvarial organ culture assay.
How to Use:
- In vitro: WAY-316606 was used at 1-10 µM final concentration in various in vitro assays.
- In vivo:n/a
Reference:
- 1. Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. (2009) Bone. 44(6):1063-8.
- 2. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. (2009) J Med Chem. 52(1):105-16.
- 3. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. (2010) Bioorg Med Chem. 18(1):190-201.
- WAY-316606_spec.pdf
- WAY-316606_MSDS.pdf
Products are for research use only. Not for human use.