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AveryusefulsmallmoleculecollectiontoimproveCRISPReditingefficacy,2mgsolideachforthefollowingcompounds:
- SCR7:aNHEJinhibitorpromotestheefficiencyofHDR4–5-foldforCRISPReditinginbothhumanandmousecelllines.
- RS-1:aRAD51-StimulatorycompoundenhancesCRISPR/Cas9-andTALEN-mediatedknock-inefficiency.
- (Z)-4-Hydroxytamoxifen:apreviouslycharacterisedasanEstrogenReceptorantagoNISTandnowfoundtoimprovegenome-editingspecificity.
- L755,507:aβ3adrenergicreceptorpartialagonistenhancesCRISPR-mediatedHDRefficiencyinhumaninducedpluripotentstemcells(iPSCs)andothercelltypes.
- Azidothymidine(AZT):areversetranscriptaseinhibitorenhancesCRISPR-mediatedsequence-specificgeneknockoutviaNHEJinhumaninducedpluripotentstemcells(iPSCs)andothercelltypes.
- Nocodazoleenhanceshomology-directedrepair(HDR)efficiency9to31%(dependingoncellcyclephase)andincreasesCas9-mediatedgeneeditingfrequencies.
- ME0328enhancesCRISPR-Cas9-mediatedHER2mutationfrequency,resultinginincreasedreductioninproliferationofHER2-positivebreastcancercells.