More Information Product Details Synonyms Product Type Properties Formula MW CAS Purity Chemicals Appearance Solubility Identity InChi Key Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet

(Z)-3-Ethyl-2-(2-oxopropylidene)-2,3-dihydrobenzo[d]thiazol-5-yl acetate; ProINDY

Chemical

C14H15NO3S

277.3

719277-30-2

≥98% (HPLC)

White to off-white solid.

Soluble in DMSO (10mg/ml).

Determined by 1H-NMR.

RLEOCVDWLAYGRX-AUWJEWJLSA-N

AMBIENT

+4°C

-20°C

Keep cool and dry.

Stable for at least 2 years after receipt when stored at -20°C.

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• Prodrug form (acetylated derivative) of INDY (Prod. No. AG-CR1-3665).
• Cell permeable ATP-competitive DYRK1A and DYRK1B inhibitor.
• Inhibits phosphorylation of Tau-protein and rescues repressed calcineurin/NFAT signaling.
• Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.

Product References

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A: Y. Ogawa, et al.; Nat. Commun. 1, 86 (2010)

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