| 货号： | FG0115 |
| Product Description： | Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. |
| Quality Control Testing： | Representative images of human breast cancer cell stain with the dual color FISH probe. The left image is two copies of HER2 genes as well as chromosome 17 in cell (normal); and the right image is two copies of chromosome 17, higher copy number of HER2 gene (amplification). |
| Storage Instruction： | Store at -20°C in the dark. |
| Note： | Hybridization position of the probes on the chromosome. |
| Probe 1 Size Fluorophore Location： | HER2 Approximately 157kb Orange 17q11.2-12 |
| Probe 2 Size Fluorophore Location： | CEN17q Approximately 1.02kb Green 17p11.1-q11.1 |
| Origin： | Human |
| Source： | Genomic DNA |
| Regulation Status： | For research use only (RUO) |
| Gene Name： | ERBB2 |
| Gene Alias： | CD340,HER-2,HER-2/neu,HER2,NEU,NGL,TKR1 |
| Gene Description： | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) |
| omim id： | , , , |
| Gene Summary： | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq |
| Other Designations： | c-erb B2/neu protein,erbB-2,herstatin,neuroblastoma/glioblastoma derived oncogene homolog,v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) |
| 规格： | 200 uL |
