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公司地址
苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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商品描述
| Description | RIPA-56isahighly-potent,selective,andmetabolicallystableRIP1(RIPK1)inhibitor. | ||
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| Targets |
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| Invitro | RIPA-56showsefficientinhibitionofRIP1kinaseactivity,withanIC50of13nM.ItshowednoinhibitionofRIP3kinaseactivityata10µMconcentration.RIPA-56doesnotinhibitIDOactivityataconcentrationof200µM,whichrepresentsanestimated10,000-foldselectivitywindowbasedontheRIP1ADP-Gloactivityof13nM[1]. | ||
| Invivo | RIPA-56hasanimpressivePKprofileinmice,witha3.1hhalf-life,22%oralbioavailABIlity(PO),and100%bioavailabilityfromintraperitonealinjection(IP).RIPA-56hasgreatabilityintransportingacrossbloodbrainbarrier.IntheSIRSmicediseasemodel,RIPA-56efficientlyreducedtumornecrosisfactoralpha(TNFα)-inducedmortalityandmulti-organdamage[1]. |
