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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
Specifications
SPECIES: | Murine |
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SOURCESPECIES: | E.coli |
SEQUENCE: | DGNTTRTPETNGSLCGAPGENCTGTTPRQKVKTHFSRCPKQYKHYCIHGRCRFVVDEQTPSCICEKGYFGARCERVDLFY |
TESTEDAPPLICATIONS: | |
BIOLOGICALACTIVITY: | BiologicalactivitywasdeterminedbyitsABIlitytostimulatetheproliferationofmouseBalb/3T3cells.TheexpectedED50is≤0.01ng/mL,correspondingtoaspecificactivityof≥1x108units/mg.Endotoxinlevelislessthan0.1ngperμg(1EU/μg). |
Properties
PURITY: | Greaterthan98%bySDS-PAGEgelandHPLCanalyses. |
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PHYSICALSTATE: | Lyophilized |
STORAGECONDITIONS: | ThelyophilizedBetacellulinrecombinantproteinisstableforatleast2yearsfromdateofreceiptat-20˚C.ReconstitutedBetacellulinstableforatleast3monthswhenstoredinworkingaliquotswithacarrierproteinat-20˚C.Aswithanyprotein,exposingBetacellulinrecombinantproteintorepeatedfreeze/thawcyclesisnotrecommended.Whenworkingwithproteinscareshouldbetakentokeeprecombinantproteinatacoolandstabletemperature. |
AdditionalInfo
ALTERNATENAMES: | Bcn,Bcn,Probetacellulin,BTC |
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ACCESSIONNO.: | NP_031594.1 |
PROTEINGINO.: | 6680812 |
Background
BetacellulinisanEGF-relatedpolypeptidegrowthfactorthatsignalsthroughtheEGFreceptor.Itisproducedinseveraltissues,includingthepancreas,smallintestine,andincertaintumorcells.Betacellulinisapotentmitogenforretinalpigmentepithelialcellsandvascularsmoothmusclecells.Betacellulinisinitiallysynthesizedasaglycosylated32.0kDatransmembraneprecursorprotein,whichisprocessedbyproteolyticcleavagetoproducethematuresequence.RecombinantmurineBetacellulinisa9.0kDamonomericprotein,containing80aminoresidues,whichcomprisesthematureEGFhomologousportionoftheBetacellulinprotein. |