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商品描述
Specifications
SPECIES: | Human |
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SOURCESPECIES: | E.coli |
SEQUENCE: | Gln25-Pro147 |
FUSIONTAG: | TagFree |
TESTEDAPPLICATIONS: | |
APPLICATIONS: | ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly. |
Properties
PURITY: | Greaterthan95%asdeterminedbyreducingSDS-PAGE. Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest. |
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PREDICTEDMOLECULARWEIGHT: | 14.27kD |
PHYSICALSTATE: | Lyophilized |
BUFFER: | Lyophilizedfroma0.2umfilteredsolutionof20mMPB,150mMNaCl,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O. |
STORAGECONDITIONS: | Lyophilizedproteinshouldbestoredat-20˚C,thoughstableatroomtemperaturefor3weeks. Reconstitutedproteinsolutioncanbestoredat4-7˚Cfor2-7days. Aliquotsofreconstitutedsamplesarestableat-20˚Cfor3months. |
AdditionalInfo
ALTERNATENAMES: | Angiogenin,Ribonuclease5,RNase5,ANG,RNASE5 |
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ACCESSIONNO.: | P03950 |
Background
Angiogeninbelongstothepancreaticribonucleasefamily.Angiogeninisprimarilyexpressedintheliver.ItmayactasatRNA-specificribonucleasethatabolishesproteinsynthesisbyspecificallyhydrolyzingcellulartRNAs.Angiogeninisapotentstimulatorofnewbloodvesselformation.AndAngiogeninisendocytosedandtranslocatedtothenucleusbybindingtoactinonthesurfaceofendothelialcells.AngiogenicactivityisregulatedbyinteractionwithRNH1invivo.Inaddition,Angiogeninisassociatedwithsusceptibilitytoamyotrophiclateralsclerosis,whichisadegenerativedisorderofmotorneuronsinthecortex,brainstemandspinalcord. |