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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
Specifications
SPECIES: | Human |
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SOURCESPECIES: | HumanCells |
SEQUENCE: | Glu20-Val751 |
FUSIONTAG: | C-6Histag |
TESTEDAPPLICATIONS: | |
APPLICATIONS: | ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly. |
Properties
PURITY: | Greaterthan95%asdeterminedbyreducingSDS-PAGE. Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest. |
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PREDICTEDMOLECULARWEIGHT: | 84.4kD |
PHYSICALSTATE: | Liquid |
BUFFER: | Suppliedasa0.2umfilteredsolutionof20mMTrisHCl,150mMNaCl,10%Glycerol,pH7.5.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O. |
STORAGECONDITIONS: | Storeat-20˚C,stablefor6monthsafterreceipt. Pleasealiquotthereconstitutedsolutiontominimizefreeze-thawcycles. |
AdditionalInfo
ALTERNATENAMES: | Amiloride-sensitiveamineoxidase[copper-containing],DAO,Diamineoxidase,Amiloride-bindingprotein1,Amineoxidasecopperdomain-containingprotein1,Histaminase,Kidneyamineoxidase,KAO,AOC1,ABP1,DAO1,ABP1,AOC1 |
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ACCESSIONNO.: | P19801 |
Background
Amiloride-sensitiveamineoxidase(AOC1)belongstothecopper/topaquinoneoxidasefamily.Theproteinexistsashomodimerbydisulfideandmainlylocatedinplacentaandkidney.AOC1catalyzesthedegradationofcompoundssuchasputrescine,histamine,spermine,andspermidine,substancesinvolvedinallergicandimmuneresponses,cellproliferation,tissuedifferentiation,tumorformation,andpossIBLyapoptosis.PlacentalDAOisthoughttoplayaroleintheregulationofthefemalereproductivefunction.Theactivityofthisproteincanbeinhibitedbyamilorideinacompetitivemanner.Itisinhibitedbyamiloride,adiureticthatactsbyclosingepithelialsodiumionchannels. |