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商品描述
Specifications
SPECIES: | Human |
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SOURCESPECIES: | E.coli |
SEQUENCE: | Met1-Lys162 |
FUSIONTAG: | N,C-6Histag |
TESTEDAPPLICATIONS: | |
APPLICATIONS: | ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly. |
Properties
PURITY: | Greaterthan95%asdeterminedbyreducingSDS-PAGE. Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest. |
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PREDICTEDMOLECULARWEIGHT: | 20.4kD |
PHYSICALSTATE: | Lyophilized |
BUFFER: | Lyophilizedfroma0.2umfilteredsolutionof20mMPB,150mMNaCl,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O. |
STORAGECONDITIONS: | Lyophilizedproteinshouldbestoredat-20˚C,thoughstableatroomtemperaturefor3weeks. Reconstitutedproteinsolutioncanbestoredat4-7˚Cfor2-7days. Aliquotsofreconstitutedsamplesarestableat-20˚Cfor3months. |
AdditionalInfo
ALTERNATENAMES: | Alpha-Taxilin,TXLNA,TXLN,IL-14 |
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ACCESSIONNO.: | P40222 |
Background
alpha-Taxilinbelongstothetaxilinfamily.alpha-Taxilinexistsinalmostalltissues,withhigherexpressionlevelsobservedintheheart,kidney,liver,andpancreas.alpha-TaxilinbindstotheC-terminalcoiledcoilregionofsyntaxinfamilymembersSTX1A,STX3A,andSTX4A,butnotwhentheseproteinsarecomplexedwithSNAP25,VAMP2orSTXBP1,suggestingthatitinteractswithsyntaxinsthatdonotformtheSNAREcomplex.Itisshownthatalpha-TaxilinplaysmultiplerolesinthegenerationandmaintenanceofneuronsthroughmodulationoftheNAC-mediatedtranslationalmachinaryand/orthesyntaxin-mediatedvesicletrafficinthesoma.Inaddition,alpha-Taxilinmaybeinvolvedinintracellularvesicletrafficandpotentiallyincalcium-dependentexocytosisinneuroendocrinecells. |