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商品描述
Specifications
SPECIES: | Mouse |
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SOURCESPECIES: | HumanCells |
SEQUENCE: | Asp23-Pro119 |
FUSIONTAG: | C-Fctag |
TESTEDAPPLICATIONS: | |
APPLICATIONS: | ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly. |
Properties
PURITY: | Greaterthan95%asdeterminedbyreducingSDS-PAGE. Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest. |
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PREDICTEDMOLECULARWEIGHT: | 38.1kD |
PHYSICALSTATE: | Lyophilized |
BUFFER: | Lyophilizedfroma0.2umfilteredsolutionofPBS,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O. |
STORAGECONDITIONS: | Lyophilizedproteinshouldbestoredat-20˚C,thoughstableatroomtemperaturefor3weeks. Reconstitutedproteinsolutioncanbestoredat4-7˚Cfor2-7days. Aliquotsofreconstitutedsamplesarestableat-20˚Cfor3months. |
AdditionalInfo
ALTERNATENAMES: | Serine/threonine-proteinkinasereceptorR3,SKR3,Activinreceptor-likekinase1,ALK-1,TGF-BsuperfamilyreceptortypeI,TSR-I,ACVRL1,activinAreceptortypeII-like1,activinAreceptor |
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ACCESSIONNO.: | Q61288 |
Background
ActivinReceptor-LikeKinase1(ALK-1)isatypeIcell-surfacereceptorfortheTGF-betasuperfamilyofligands,whichmediatessignalingofBMP9(bonemorphogeneticprotein)andBMP10.ALK1signalingisnecessaryforangiogenesisduringembryogenesis,woundhealing,andtumorgrowth.ALK-1hasahighdegreeofsimilarityinserine-threoninekinasesuBDomains,aglycineandserinerichregionprecedingthekinase-domain,andaC-terminaltailwithotheractivinreceptor-likekinaseproteins.ALK-1ismainlyexpressedinendothelialcellsregulatingproliferationandmigrationinvitroandangiogenesisinvivo.MutationsinALK-1aswellasinendoglinareassociatedwithhereditaryhemorrhagictelangiectasia(HHT),suggestingALK-1playsacriticalroleforinthecontrolofbloodvesseldevelopmentorrepair. |