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商品描述
Specifications
SPECIES: | Human |
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SOURCESPECIES: | E.coli |
SEQUENCE: | GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS |
TESTEDAPPLICATIONS: | |
BIOLOGICALACTIVITY: | TheED50wasdeterminedbyitsABIlitytoinhibittheproliferationofmurineMPC-11cellsis≤2.0ng/mL,correspondingtoaspecificactivityof≥5x105units/mg. |
Properties
PURITY: | Greaterthan97%bySDS-PAGEgelandHPLCanalyses. Endotoxinlevelislessthan0.1ngperμg(1EU/μg). |
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PHYSICALSTATE: | Lyophilized |
STORAGECONDITIONS: | ThelyophilizedActivinArecombinantproteinisstableforatleast2yearsfromdateofreceiptat-20˚C.ReconstitutedActivinAisstableforatleast3monthswhenstoredinworkingaliquotswithacarrierproteinat-20˚C.Aswithanyprotein,exposingActivinArecombinantproteintorepeatedfreeze/thawcyclesisnotrecommended.Whenworkingwithproteinscareshouldbetakentokeeprecombinantproteinatacoolandstabletemperature. |
AdditionalInfo
ALTERNATENAMES: | JV18,MADH2,MADR2,JV18-1,hMAD-2,hSMAD2,Mothersagainstdecapentaplegichomolog2,MADhomolog2 |
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ACCESSIONNO.: | NP_001003652.1 |
PROTEINGINO.: | 51173730 |
Background
ActivinAisaTGF-βfamilymemberthatexhibitsawiderangeofbiologicalactivitiesincludingregulationofcellularproliferationanddifferentiation,andpromotionofneuronalsurvival.ElevatedlevelsofActivinAinhumancolorectaltumorsandinpostmenopausalwomenhavebeenimplicatedincolorectalandbreastcancers,respectively.ThebiologicalactivitiesofActivinAcanbeneutralizedbyinhibinsandbythediffusIBLeTGF-βantagoNIST,follistatin.HumanActivinAisa26.0kDadisulfide-linkedhomodimeroftwoβAchains,eachcontaining116aminoacidresidues. |