Vasoactiveintestinalpeptide(VIP)andthestructurallyrelatedpituitaryadenylatecyclase-activatingpolypeptide(PACAP),twoneuropeptidespresentinthelymphoidmicroenvironment,elicitabroadspectrumofBIOLOGicalfunctions,includingthemodulationofinnateandadaptiveimmunity.AnotherimportantimmunoregulatoryfunctionofVIPandPACAPistheirinhibitioneffectonAICDinTcells.TheyinhibittheTCR-stimulatedFasLexpressionandapoptosisofTcellthroughspecificreceptorsandinductionofintracellularcAMP.VIPdown-regulatec-Mycsynthesis,theNF-AT-dependentEgr2andEgr3expression,theNF-ATandNF-kB.

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REFERENCES:DelgadoM,GaneaD.Vasoactiveintestinalpeptideandpituitaryadenylatecyclase-activatingpolypeptideinhibitexpressionofFasligandinactivatedTlymphocytesbyregulatingc-Myc,NF-kappaB,NF-AT,andearlygrowthfactors2/3.JImmunol2001Jan15;166(2):1028-40

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