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AMG51

Chemical

C34H33F2N5O5

629.7

890019-63-3

≥95%

Solid.

Soluble in DMSO.

Manufactured by SynKinase.

Target: c-Met > mTOR | Kinase Group: Atypical (PIKK) | Substrate: Serine-ThreonineClick here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet.

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AMBIENT

+4°C

-20°C

Stable for at least 2 years after receipt when stored at -20°C.

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c-Met kinase is the receptor for hepatocyte growth factor (HGFR). Primarily expressed on epithelial and mesenchymal cells its normal function is associated with wound healing, liver regeneration and embryo development. However, dysregulation of c-Met through overexpression, gene amplification, mutation or a ligand-dependent autocrine/paracrine loop is associated with tumorigenesis. c-Met dysregulation in human cancer patients is typically associated with a poor prognosis, aggressive disease, increased metastasis and shortened patient survival. Targeting the hepatocyte growth factor/c-Met signalling pathway as a means of cancer therapy has, therefore, become increasingly popular with a number of different therapeutic approaches undergoing clinical trials. AMG-51 represents a modified novel pyrimidone 7 compound that demonstates good effectiveness against c-Met with few off target effects at set concentrations. AMG-51 shows the enzyme selectivity of c-Met with a Ki of 4.9nM, with off target proteins such as IGFR with a Ki of 22nM, Ron with a Ki of 28nM, and KDR with Ki of 139nM.Product References

Design, synthesis, and biological evaluation of potent c-Met inhibitors: N.D. DAngelo, et al.; J. Med. Chem. 51, 5766 (2008)

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