Product Specification:
| Alternative Name: | Core-binding factor α3 subunit, AML-2, Acute myeloid leukemia 2 protein, CBF-α3, Runt-related transcription factor 3 |
| Clone: | R3-6E9 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human RUNX3 (runt-related transcription factor 3) (aa 191-300). |
| UniProt ID: | Q13761 |
| Species reactivity: | Human |
| Crossreactivity: | Weakly cross-reacts with mouse RUNX3. |
| Applications: | IHC (PS), IP, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections, 2µg/ml)Western Blot (0.2µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Formulation: | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
| Shipping: | Shipped on Blue Ice |
| Short Term Storage: | +4°C |
| Long Term Storage: | -20°C |
| Scientific Background: | RUNX (Runt-related transcription factor) family members play important roles in normal developmental processes and carcinogenesis. Of the three known RUNX family members, the ubiquitously expressed RUNX3 is involved in neurogenesis, T cell differentiation, tumorigenesis and is a component of the TGF-β induced tumor suppressor pathway. In gastric cancer cells, RUNX3 induces cell cycle arrest and apoptosis through upregulation of Bim, a proapoptotic BH3-only protein. In addition, RUNX3 is frequently inactivated in gastric cancer cells. |
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