Description:

Interleukin-10, also called cytokine synthesis inhibitory factor, is implicated in tumorigenesis, and it has been shown that polymorphisms in its gene promoter correlate with differential amounts of production. IL-10 is an important cytokine with anti-inflammatory, anti-immune, and antifibrotic functions. It is also an important regulatory cytokine whose involvement extends into diverse areas of the human immune system. IL-10 is a recently described natural endogenous immunosuppressive cytokine that has been identified in human, murine, and other organisms. IL-10 significantly affects chemokine biology, because human IL-10 inhibits chemokine production and is a specific chemotactic factor for CD8+ T cells. It suppresses the ability of CD4+ T cells, but not CD8+ T cells, to migrate in response to IL-8. Interleukin-10 gene polymorphisms and interleukin-10 production capability may contribute to the development of skin squamous cell carcinomas after renal transplantation. The interleukin-10 locus contributes to the heritability of psoriasis susceptibility. With regard to sudden infant death, IL-10 is of special interest. This is an immunoregulatory cytokine that plays an important role in the development of infectious disease. The mIL-10 gene is mapped to mouse chromosome 1 and the hIL-10 gene is also mapped to human chromosome 1. The standard product used in this kit is recombinant mouse IL-10, consisting of 160 amino acid with the molecular mass of 18KDa.

Additional Information:

Name Related Product Names Short Description Immunogen Standard Range Sample Type Specimen/Volumes Swiss Prot Number Concentration Applications GI Number Stability Reactivity Kit Size Storage Intended Use

Mouse IL-10 ELISA Kit

CSIF|Cytokine synthesis inhibitory factor|GVHDS|IL 10|IL-10|IL10|IL10_HUMAN|IL10A|Interleukin 10|Interleukin-10|Interleukin10|MGC126450|MGC126451|T cell growth inhibitory factor|TGIF

Sandwich ELISA kit of Quantitative Detection for Mouse IL-10

E.coli, S19-S178

15.6pg/ml-1000pg/ml. Test has a sensitivity of

This kit is used for quantitative detection of mouse IL-10 in cell culture supernates and serum.

Refer to Manual

P18893

Lot Specific

ELISA

16153

Four months at 4C and eight months at -20C.

Reactive to Mouse. There is no detectable cross-reactivity with other relevant proteins.

1x96 well plate

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Research Use Only

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