Ran is a member of the Ras family of small GTPases. Ran is an important component of many crucial nucleocytoplasmic transport pathways. The cycling of Ran is controlled by the RanGTP- RanGDP gradient established by the Ran Guanine nucleotide exchange Factor (RanGEF) RCC1 and the Ran GTPase-activating Protein (RanGAP). These two proteins combine to create a Ran gradient where RanGDP is predominantly cytoplasmic. RCC1 binds to chromatin and so RanGTP is found associated with DNA. RCC1 dissociated GDP from Ran and allows GTP to be bound. As Ran leaves the nucleus The two Ran binding proteins, RanBP1 and RanBP2 cooperate with RanGAP to induce GTP hydrolysis of Ran. There are several nuclear import factors that use the Ran gradient as part of their translocation mechanism

Contributor:

REFERENCES: Kuersten S, Ohno M, Mattaj IW. Nucleocytoplasmic transport: Ran, beta and beyond. Trends Cell Biol. 2001 Dec;11(12):497-503. Review.

相关信息SynapticProteinsattheSynapticJunction 2011/11/7PrionPathway 2011/11/7PrionPathway 2011/11/7Generationofamyloidb-peptidebyPS1 2011/11/7Generationofamyloidb-peptidebyPS1 2011/11/7Gamma-aminobutyricAcidReceptorLifeCycle 2011/11/7Gamma-aminobutyricAcidReceptorLifeCycle 2011/11/7EndocytoticroleofNDK,PhosphinsandDynamin 2011/11/7EndocytoticroleofNDK,PhosphinsandDynamin 2011/11/7DeregulationofCDK5inAlzheimersDisease 2011/11/7DeregulationofCDK5inAlzheimersDisease 2011/11/7BlockadeofNeurotransmitterRelasebyBotulin 2011/11/7Thesalvagepathwayfromserinetophosphatidy 2011/11/7TheroleofFYVE-fingerproteinsinvesicletr 2011/11/7TheroleofFYVE-fingerproteinsinvesicletr 2011/11/7
联系人：蚂蚁淘编辑部
Email：service@bioon.com
电话：021-54485309
传真：021-54485087

>>> 更多资讯详情请访问蚂蚁淘商城