Thepurposeofthisstudywastoinvestigateandcompareadjuvanteffectsofsolubleβ-glucansfrombarleyand
Saccharomychescerevisiaininductionofantigenspecifichumoralimmuneresponses.Micewereimmunizedwithconalbuminatarelativelylowconcentrationinthepresenceofbetaglucans.Anti-conalbuminantibodiesintheseraofimmunizedandcontrolmicewerequantifiedby
ELISA.Athighdoses,bothofglucansincreasedeffectivelylevelsofcirculatingIgMandIgGantibodieswhichwerespecificforconalbumin.However,coadmi
NISTrationofglucanfrombarleyat1μgdoseresultedinloweryieldinIgG1,IgG2a,IgG2b,andIgAlevelsincomparisontothatofyeast-derivedglucanatthesamedose.Wealsofoundthatantigen(conalbumin)specificantibodylevelsenhancedbyβ-glucanfrom
Saccharomychescerevisiawerealwayshigherthanthoseoftheglucanfrombarley.Basedonthesefindings,weconcludedthat(1,3),(1,6)-β-D-glucanfromyeastcellwallmighthavesuperiorimmunostimulantactivityininductionofantigenspecifichumoralimmuneresponsesover(1,3),(1,4)-β-D-glucanfrombarley.