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商品描述
Highpurityβ-Glucan(Yeast;AlkaliSoluble)foruseinresearch,biochemicalenzymeassaysandinvitrodiagnosticanalysis.
Purity~90%.Extractedfromyeastcellswithhotalkaliandpurified.
DifferentialadjuvanteffectsofsolublebetaglucansfrombarleyandSaccharomychescerevisiainprimaryandsecondaryhumoralimmuneresponses.
Uslu,K.&Bagriacik,E.U.(2011).InternationalJournalofHematology&Oncology/UHOD:UluslararasiHematolojiOnkolojiDergisi,21(3).
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Thepurposeofthisstudywastoinvestigateandcompareadjuvanteffectsofsolubleβ-glucansfrombarleyandSaccharomychescerevisiaininductionofantigenspecifichumoralimmuneresponses.Micewereimmunizedwithconalbuminatarelativelylowconcentrationinthepresenceofbetaglucans.Anti-conalbuminantibodiesintheseraofimmunizedandcontrolmicewerequantifiedbyELISA.Athighdoses,bothofglucansincreasedeffectivelylevelsofcirculatingIgMandIgGantibodieswhichwerespecificforconalbumin.However,coadmiNISTrationofglucanfrombarleyat1μgdoseresultedinloweryieldinIgG1,IgG2a,IgG2b,andIgAlevelsincomparisontothatofyeast-derivedglucanatthesamedose.Wealsofoundthatantigen(conalbumin)specificantibodylevelsenhancedbyβ-glucanfromSaccharomychescerevisiawerealwayshigherthanthoseoftheglucanfrombarley.Basedonthesefindings,weconcludedthat(1,3),(1,6)-β-D-glucanfromyeastcellwallmighthavesuperiorimmunostimulantactivityininductionofantigenspecifichumoralimmuneresponsesover(1,3),(1,4)-β-D-glucanfrombarley.


