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Silicon Phthalocyanine 4 | Pc-4 | CAS#135719-28-7 | Photosensitizer | MedKoo

作者: 时间:2025-01-31 点击量:

Silicon Phthalocyanine 4, also known as Pc-4, is a drug potentially for the treatment of cutaneous neoplasms. Photoirradiation of the silicon phthalocyanine 4 photosensitizer with red light generates singlet oxygen and other reactive oxygen species to induce cell death. Pc 4 is absorbed into the epidermis in as little as 1 hour and the absorption increased with increasing time and dose. Silicon phthalocyanine 4 can be effectively delivered into human skin via topical application. Price and Availability

Silicon Phthalocyanine 4 (Pc-4) is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually 98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote. 19-(((3-(dimethylamino)propyl)dimethylsilyl)oxy)-19H-6,11-(azeno)-17,21-(azeno[1]episoindoloazeno)benzo[7,8][1,3,5,10]tetraaza[2]silacycloundecino[4,3-a:11,1-a\']diisoindol-19-olInChi Key: MQPOIOMXRKFQLZ-XSRQUKKKSA-NInChi Code: InChI=1S/C39H35N9O2Si2/c1-46(2)22-13-23-51(3,4)50-52(49)47-36-28-18-9-10-19-29(28)38(47)44-34-26-16-7-8-17-27(26)35(41-34)45-39-31-21-12-11-20-30(31)37(48(39)52)43-33-25-15-6-5-14-24(25)32(40-33)42-36/h5-12,14-21,49H,13,22-23H2,1-4H3/b42-32-,42-36-,43-33-,43-37-,44-34-,44-38-,45-35-,45-39-SMILES Code: O[Si]1(O[Si](C)(C)CCCN(C)C)N2/C(C3=C(C=CC=C3)/C2=N/C4=N/C(C5=C4C=CC=C5)=N\\6)=N\\C(C7=C/8C=CC=C7)=NC8=N/C9=C(C=CC=C%10)C%10=C6N91 Technical Data Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

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7: Lam M, Hsia AH, Liu Y, Guo M, Swick AR, Berlin JC, McCormick TS, Kenney ME, Oleinick NL, Cooper KD, Baron ED. Successful cutaneous delivery of the photosensitizer silicon phthalocyanine 4 for photodynamic therapy. Clin Exp Dermatol. 2011 Aug;36(6):645-51. doi: 10.1111/j.1365-2230.2010.03989.x. Review. PubMed PMID: 21623875; PubMed Central PMCID: PMC3140567.

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9: Baron ED, Malbasa CL, Santo-Domingo D, Fu P, Miller JD, Hanneman KK, Hsia AH, Oleinick NL, Colussi VC, Cooper KD. Silicon phthalocyanine (Pc 4) photodynamic therapy is a safe modality for cutaneous neoplasms: results of a phase 1 clinical trial. Lasers Surg Med. 2010 Dec;42(10):728-35. doi: 10.1002/lsm.20984. PubMed PMID: 21246576; PubMed Central PMCID: PMC3149858.

10: Yang Y, Samas B, Kennedy VO, Macikenas D, Chaloux BL, Miller JA, Speer RL Jr, Protasiewicz J, Pinkerton AA, Kenney ME. Long, directional interactions in cofacial silicon phthalocyanine oligomers. J Phys Chem A. 2011 Nov 17;115(45):12474-85. doi: 10.1021/jp2019445. PubMed PMID: 21805980.

11: Céspedes-Guirao FJ, Martín-Gomis L, Ohkubo K, Fukuzumi S, Fernández-Lázaro F, Sastre-Santos A. Synthesis and photophysics of silicon phthalocyanine-perylenebisimide triads connected through rigid and flexible bridges. Chemistry. 2011 Aug 8;17(33):9153-63. doi: 10.1002/chem.201100320. PubMed PMID: 21714016.

12: Lam M, Dimaano ML, Oyetakin-White P, Retuerto MA, Chandra J, Mukherjee PK, Ghannoum MA, Cooper KD, Baron ED. Silicon phthalocyanine 4 phototoxicity in Trichophyton rubrum. Antimicrob Agents Chemother. 2014 Jun;58(6):3029-34. doi: 10.1128/AAC.01448-13. PubMed PMID: 24614382; PubMed Central PMCID: PMC4068425.

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14: Kinsella TJ, Baron ED, Colussi VC, Cooper KD, Hoppel CL, Ingalls ST, Kenney ME, Li X, Oleinick NL, Stevens SR, Remick SC. Preliminary clinical and pharmacologic investigation of photodynamic therapy with the silicon phthalocyanine photosensitizer pc 4 for primary or metastatic cutaneous cancers. Front Oncol. 2011 Jun 30;1:14. doi: 10.3389/fonc.2011.00014. PubMed PMID: 22649754; PubMed Central PMCID: PMC3355859.

15: Lam M, Lee Y, Deng M, Hsia AH, Morrissey KA, Yan C, Azzizudin K, Oleinick NL, McCormick TS, Cooper KD, Baron ED. Photodynamic therapy with the silicon phthalocyanine pc 4 induces apoptosis in mycosis fungoides and sezary syndrome. Adv Hematol. 2010;2010:896161. doi: 10.1155/2010/896161. PubMed PMID: 21197103; PubMed Central PMCID: PMC3004392.

16: Ermilov EA, Liu JY, Ng DK, Röder B. Spectroscopic study of electron and energy transfer in novel silicon phthalocyanine--boron dipyrromethene triads. Phys Chem Chem Phys. 2009 Aug 14;11(30):6430-40. doi: 10.1039/b823432a. PubMed PMID: 19809675.

17: Martín-Gomis L, Ohkubo K, Fernández-Lázaro F, Fukuzumi S, Sastre-Santos A. Multistep electron transfer systems based on silicon phthalocyanine, [60]fullerene and trinitrofluorenone. Chem Commun (Camb). 2010 Jun 14;46(22):3944-6. doi: 10.1039/c002077j. PubMed PMID: 20419189.

18: Ozawa K, Ishii K. Photophysical and magnetic properties of magnetic silica gel-supported silicon phthalocyanine complexes. Phys Chem Chem Phys. 2009 Feb 21;11(7):1019-22. doi: 10.1039/b811128f. PubMed PMID: 19543597.

19: Ishii K, Sakai N. Wavelength-tunable excited-state absorption and optical limiting effects in the Q band region based on silicon phthalocyanine oligomers. Phys Chem Chem Phys. 2010 Dec 21;12(47):15354-7. doi: 10.1039/c0cp01172j. PubMed PMID: 20941425.

20: Zhang GC, Huang JD, Chen YM, Sun JC, Liu H, Chen NS, Huang JL. [A silicon phthalocyanine axially substituted by nipagin: synthesis, molecular spectroscopic properties, and in vitro photodynamic activities]. Guang Pu Xue Yu Guang Pu Fen Xi. 2005 Oct;25(10):1622-6. Chinese. PubMed PMID: 16395898.

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