Aristolochic acid, also known as Aristolochic acid A and AristA, is a carcinogen found in Aristolochia and Radix. It inhibits PLA2 and decreases GABA-induced release of arachidonic acid and phosphatidylcholine. Aristolochic acid A was used in traditional medicines to treat pain. Balkan endemic nephropathy (BEN) is a renal disease associated with AristA consumption Price and Availability

Aristolochic acid A, purity 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order 2.0 g may be 2 weeks. Aristolochin; Birthwort; NSC-11926; NSC 11926; NSC11926; NSC-50413; NSC50413; NSC 50413; TR-1736; Aristolochic acid I; Aristolochic acid A; Tardolyt ; AristAIUPAC/Chemical Name: 8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acidInChi Key: BBFQZRXNYIEMAW-UHFFFAOYSA-NInChi Code: InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)SMILES Code: O=C(C1=CC(OCO2)=C2C3=C4C=CC=C(OC)C4=CC([N+]([O-])=O)=C13)O Technical Data Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

1: Guan T, Huang K, Liu Y, Hou S, Hu C, Li Y, Zhang J, Zhao J, Zhang J, Wang R, Huang Y. Aristolochic acid inhibits Slit2-induced migration and tube formation via inactivation of Robo1/Robo2-NCK1/NCK2 signaling pathway in human umbilical vein endothelial cells. Toxicol Lett. 2019 Jan;300:51-58. doi: 10.1016/j.toxlet.2018.10.022. Epub 2018 Oct 28. PubMed PMID: 30381256.

2: Honarpisheh M, Foresto-Neto O, Steiger S, Kraft F, Koehler P, von Rauchhaupt E, Potempa J, Adamowicz K, Koziel J, Lech M. Aristolochic acid I determine the phenotype and activation of macrophages in acute and chronic kidney disease. Sci Rep. 2018 Aug 15;8(1):12169. doi: 10.1038/s41598-018-30628-x. PubMed PMID: 30111809; PubMed Central PMCID: PMC6093867.

3: Kholia S, Herrera Sanchez MB, Cedrino M, Papadimitriou E, Tapparo M, Deregibus MC, Brizzi MF, Tetta C, Camussi G. Human Liver Stem Cell-Derived Extracellular Vesicles Prevent Aristolochic Acid-Induced Kidney Fibrosis. Front Immunol. 2018 Jul 19;9:1639. doi: 10.3389/fimmu.2018.01639. eCollection 2018. PubMed PMID: 30072992; PubMed Central PMCID: PMC6060249.

4: Marin DE, Pistol GC, Gras M, Palade M, Taranu I. A comparison between the effects of ochratoxin A and aristolochic acid on the inflammation and oxidative stress in the liver and kidney of weanling piglets. Naunyn Schmiedebergs Arch Pharmacol. 2018 Oct;391(10):1147-1156. doi: 10.1007/s00210-018-1538-9. Epub 2018 Jul 22. PubMed PMID: 30033502.

5: Shu H, Ge Y, Xu XY, Guo PQ, Luo ZM, Du W, Chang C, Liu RL, Fu Q. Hybrid-type carbon microcoil-chitosan composite for selective extraction of aristolochic acid I from Aristolochiaceae medicinal plants. J Chromatogr A. 2018 Aug 3;1561:13-19. doi: 10.1016/j.chroma.2018.05.037. Epub 2018 May 18. PubMed PMID: 29803429.

6: Chang MM, Lin CN, Fang CC, Chen M, Liang PI, Li WM, Yeh BW, Cheng HC, Huang BM, Wu WJ, Chen YA. Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes. Sci Rep. 2018 May 3;8(1):6960. doi: 10.1038/s41598-018-22298-6. PubMed PMID: 29725048; PubMed Central PMCID: PMC5934382.

7: Liu X, Cao J, Pan Y, Zhang X. Fermentation of Aristolochia debilis by six different medicinal fungi and identification of aristolochic acid derivates in their products by HPLC-ESI-TOF-MS. Pak J Pharm Sci. 2018 May;31(3):763-768. PubMed PMID: 29716853.

8: Ji X, Feng G, Chen G, Shi T. Lack of correlation between aristolochic acid exposure and hepatocellular carcinoma. Sci China Life Sci. 2018 Jun;61(6):727-728. doi: 10.1007/s11427-018-9288-1. Epub 2018 Apr 20. PubMed PMID: 29700703.

9: Chen CJ, Yang YH, Lin MH, Lee CP, Tsan YT, Lai MN, Yang HY, Ho WC, Chen PC; Health Data Analysis in Taiwan (hDATa) Research Group. Herbal medicine containing aristolochic acid and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection. Int J Cancer. 2018 Apr 18. doi: 10.1002/ijc.31544. [Epub ahead of print] PubMed PMID: 29667191.

10: Huang YT, Wu TS, Lu CC, Yu FY, Liu BH. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicol Lett. 2018 Jul;291:129-137. doi: 10.1016/j.toxlet.2018.03.032. Epub 2018 Apr 12. PubMed PMID: 29655784.

11: Baudoux T, Husson C, De Prez E, Jadot I, Antoine MH, Nortier JL, Hougardy JM. CD4(+) and CD8(+) T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy. Sci Rep. 2018 Mar 28;8(1):5334. doi: 10.1038/s41598-018-23565-2. PubMed PMID: 29593222; PubMed Central PMCID: PMC5871862.

12: Ban TH, Min JW, Seo C, Kim DR, Lee YH, Chung BH, Jeong KH, Lee JW, Kim BS, Lee SH, Choi BS, Han JS, Yang CW. Update of aristolochic acid nephropathy in Korea. Korean J Intern Med. 2018 Sep;33(5):961-969. doi: 10.3904/kjim.2016.288. Epub 2018 Mar 20. PubMed PMID: 29551056; PubMed Central PMCID: PMC6129635.

13: Simões ML, Hockley SL, Schwerdtle T, da Costa GG, Schmeiser HH, Phillips DH, Arlt VM. Erratum to Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53 [Toxicol. Appl. Pharmacol. 232(1) (2008) 86-98]. Toxicol Appl Pharmacol. 2018 Apr 1;344:75. doi: 10.1016/j.taap.2018.02.010. Epub 2018 Feb 20. PubMed PMID: 29471084.

14: Gruia AT, Oprean C, Ivan A, Cean A, Cristea M, Draghia L, Damiescu R, Pavlovic NM, Paunescu V, Tatu CA. Balkan endemic nephropathy and aristolochic acid I: an investigation into the role of soil and soil organic matter contamination, as a potential natural exposure pathway. Environ Geochem Health. 2018 Aug;40(4):1437-1448. doi: 10.1007/s10653-017-0065-9. Epub 2017 Dec 29. PubMed PMID: 29288399.

15: Gao Y, Xiao XH, Zhu XX, Liang AH, Zhang BL. [Study and opinion on toxicity of aristolochic acid]. Zhongguo Zhong Yao Za Zhi. 2017 Nov;42(21):4049-4053. doi: 10.19540/j.cnki.cjcmm.2017.0160. Chinese. PubMed PMID: 29271138.

16: Zhong W, Zhang L, Ma J, Shao S, Lin R, Li X, Xiong G, Fang D, Zhou L. Impact of aristolochic acid exposure on oncologic outcomes of upper tract urothelial carcinoma after radical nephroureterectomy. Onco Targets Ther. 2017 Dec 5;10:5775-5782. doi: 10.2147/OTT.S148641. eCollection 2017. PubMed PMID: 29255365; PubMed Central PMCID: PMC5722008.

17: Man YL, Rui HL, Chen YP, Wang GQ, Sun LJ, Cheng H. Aristolochic Acid-Induced Autophagy Promotes Epithelial-to-Myofibroblast Transition in Human Renal Proximal Tubule Epithelial Cells. Evid Based Complement Alternat Med. 2017;2017:9596256. doi: 10.1155/2017/9596256. Epub 2017 Oct 18. PubMed PMID: 29234448; PubMed Central PMCID: PMC5664270.

18: Li J, Zhang M, Mao Y, Li Y, Zhang X, Peng X, Yu F. The potential role of aquaporin 1 on aristolochic acid I induced epithelial mesenchymal transition on HK-2 cells. J Cell Physiol. 2018 Jun;233(6):4919-4925. doi: 10.1002/jcp.26310. Epub 2018 Jan 2. PubMed PMID: 29215709.

19: Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL. Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. JCI Insight. 2017 Nov 16;2(22). pii: 95978. doi: 10.1172/jci.insight.95978. [Epub ahead of print] PubMed PMID: 29202460; PubMed Central PMCID: PMC5752374.

20: Martínek V, Bárta F, Hodek P, Frei E, Schmeiser HH, Arlt VM, Stiborová M. Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches. Monatsh Chem. 2017;148(11):1971-1981. doi: 10.1007/s00706-017-2014-9. Epub 2017 Jul 26. PubMed PMID: 29104318; PubMed Central PMCID: PMC5653735.

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