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Umespirone | CAS#107736-98-1 | antipsychotic | MedKoo

作者: 时间:2025-01-31 点击量:

Umespirone is a potential antipsychotic/anxiolytic drug of the azapirone class which possesses anxiolytic and antipsychotic properties. Price and Availability

Umespirone is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually 98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote. 3,7-Diazabicyclo(3.3.1)nonane-2,4,6,8-tetrone, 3-butyl-7-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-9,9-dimethyl-InChi Key: BXNRTMZZILHVNJ-UHFFFAOYSA-NInChi Code: InChI=1S/C28H40N4O5/c1-5-6-14-31-24(33)22-26(35)32(27(36)23(25(31)34)28(22,2)3)15-10-9-13-29-16-18-30(19-17-29)20-11-7-8-12-21(20)37-4/h7-8,11-12,22-23H,5-6,9-10,13-19H2,1-4H3SMILES Code: O=C(N(CCCC)C(C1C(N2CCCCN3CCN(C4=CC=CC=C4OC)CC3)=O)=O)C(C1(C)C)C2=O Technical Data Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

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1: Holland RL, Wesnes K, Dietrich B. Single dose human pharmacology of umespirone. Eur J Clin Pharmacol. 1994;46(5):461-8. PubMed PMID: 7957544.

2: Barnes NM, Costall B, Domeney AM, Gerrard PA, Kelly ME, Krähling H, Naylor RJ, Tomkins DM, Williams TJ. The effects of umespirone as a potential anxiolytic and antipsychotic agent. Pharmacol Biochem Behav. 1991 Sep;40(1):89-96. PubMed PMID: 1685786.

3: Itzhak Y, Ruhland M, Krähling H. Binding of umespirone to the sigma receptor: evidence for multiple affinity states. Neuropharmacology. 1990 Feb;29(2):181-4. PubMed PMID: 1970425.

4: Schmidt WJ, Krähling H, Ruhland M. Antagonism of AP-5-induced sniffing stereotypy links umespirone to atypical antipsychotics. Life Sci. 1991;48(6):499-505. PubMed PMID: 1671523.

5: Ahlenius S, Wijkström A. Mixed agonist-antagonist properties of umespirone at neostriatal dopamine receptors in relation to its behavioral effects in the rat. Eur J Pharmacol. 1992 Nov 3;222(1):69-74. PubMed PMID: 1361441.

6: Schmidt J, Borchers F. Thermospray tandem mass spectrometric (TS MS-MS) investigation of the main metabolite of umespirone (KC-9172). Biol Mass Spectrom. 1992 Nov;21(11):610-3. PubMed PMID: 1360818.

7: Krähling H, Fuchs A, Ruhland M, Schön U, Mol F, Tulp M. KC 9172 (free base of KC 7218)--an antipsychotic/anxiolytic compound. II. Discrimination from typical neuroleptics and benzodiazepine-like minor tranquilizers. Pharmacopsychiatry. 1988 Nov;21(6):399-401. PubMed PMID: 2907650.

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9: De Beun R, Rijk HW, Broekkamp CL. Cross-familiarisation conditioned taste aversion procedure as a method to reveal stimulus resemblance between drugs: studies on the 5-HT1A agonist 8-OHDPAT. Psychopharmacology (Berl). 1993;112(1):121-8. PubMed PMID: 7871000.

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