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Ceanothic acid | CAS# 21302-79-4 | Anticancer Reagent | MedKoo

作者: 时间:2025-01-30 点击量:

Ceanothic acid, the A-1 homologue of betulinic acid, is isolated from Ceanothus americanus. Synthesized compounds from ceanothic acid have been shown to inhibit Epstein-Barr virus early antigen activation in anti-cancer research. It also demonstrates growth inhibitory effect against Streptococcus mutans, Actinomyces viscosus, Porphyromonas gingivalis, and Prevotella. Price and Availability

Ceanothic acid is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually 98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote. (1R,2R,3aR,5aR,5bR,7aR,10S,10aR,10bR,12aR,12bR)-2-hydroxy-3,3,5a,5b,12b-pentamethyl-10-(prop-1-en-2-yl)octadecahydrodicyclopenta[a,i]phenanthrene-1,7a(1H)-dicarboxylic acidInChi Key: WLCHQSHZHFLMJH-GOWUPVHISA-NInChi Code: InChI=1S/C30H46O5/c1-16(2)17-10-13-30(25(34)35)15-14-27(5)18(21(17)30)8-9-20-28(27,6)12-11-19-26(3,4)23(31)22(24(32)33)29(19,20)7/h17-23,31H,1,8-15H2,2-7H3,(H,32,33)(H,34,35)/t17-,18-,19+,20+,21-,22-,23-,27-,28-,29+,30-/m1/s1SMILES Code: C[C@@]1([C@]2(C)CC3)CC[C@@H](C(C)(C)[C@@H]([C@@H]4C(O)=O)O)[C@@]4(C)[C@H]1CC[C@@H]2[C@@H]5[C@@]3(C(O)=O)CC[C@@H]5C(C)=C Technical Data Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

1: Lee SS, Chen WC, Huang CF, Su Y. Preparation and cytotoxic effect of ceanothic acid derivatives. J Nat Prod. 1998 Nov;61(11):1343-7. PubMed PMID: 9834149.

2: Guo S, Duan JA, Zhao JL, Qian DW, Zhang WJ. [Chemical constituents from seeds of Ziziphus mauritiana]. Zhong Yao Cai. 2014 Mar;37(3):432-5. Chinese. PubMed PMID: 25174108.

3: Su Y, Chang CL, Lee SS, Chen WC, Huang CF. In vitro cytotoxic activity of 1-decarboxy-3-oxo-ceanothic acid in a human ovarian adenocarcinoma cell line. Res Commun Mol Pathol Pharmacol. 1998 Jun;100(3):313-26. PubMed PMID: 9730010.

4: Nakagawa-Goto K, Yamada K, Taniguchi M, Tokuda H, Lee KH. Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3378-81. doi: 10.1016/j.bmcl.2009.05.050. Epub 2009 May 18. PubMed PMID: 19481937; PubMed Central PMCID: PMC2747314.

5: Suksamrarn S, Panseeta P, Kunchanawatta S, Distaporn T, Ruktasing S, Suksamrarn A. Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana. Chem Pharm Bull (Tokyo). 2006 Apr;54(4):535-7. PubMed PMID: 16595959.

6: Ji CJ, Zeng GZ, Han J, He WJ, Zhang YM, Tan NH. Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6377-80. doi: 10.1016/j.bmcl.2012.08.074. Epub 2012 Aug 26. PubMed PMID: 22989532.

7: Guo S, Duan JA, Tang Y, Su S, Shang E, Ni S, Qian D. High-performance liquid chromatography--two wavelength detection of triterpenoid acids from the fruits of Ziziphus jujuba containing various cultivars in different regions and classification using chemometric analysis. J Pharm Biomed Anal. 2009 Jul 12;49(5):1296-302. doi: 10.1016/j.jpba.2009.03.006. Epub 2009 Mar 20. PubMed PMID: 19359121.

8: Guo S, Duan JA, Tang Y, Qian Y, Zhao J, Qian D, Su S, Shang E. Simultaneous qualitative and quantitative analysis of triterpenic acids, saponins and flavonoids in the leaves of two Ziziphus species by HPLC-PDA-MS/ELSD. J Pharm Biomed Anal. 2011 Sep 10;56(2):264-70. doi: 10.1016/j.jpba.2011.05.025. Epub 2011 May 20. PubMed PMID: 21665400.

9: Li XC, Cai L, Wu CD. Antimicrobial compounds from Ceanothus americanus against oral pathogens. Phytochemistry. 1997 Sep;46(1):97-102. PubMed PMID: 9276981.

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