MedKoo Cat#: 405650 Name: ZM336372 CAS#: 208260-29-1 Chemical Formula: C23H23N3O3 Exact Mass: 389.17394 Molecular Weight: 389.45 Elemental Analysis: C, 70.93; H, 5.95; N, 10.79; O, 12.32
Synonym: ZM336372 ZM-336372; ZM 336372
IUPAC/Chemical Name: 3-(Dimethylamino)- N -[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide
InChi Key: PYEFPDQFAZNXLI-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
SMILES Code: O=C(NC1=CC=C(C)C(NC(C2=CC=C(O)C=C2)=O)=C1)C3=CC=CC(N(C)C)=C3
Technical Data
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Certificate of Analysis: View CoA: current batch of CoA, Lot#CRB50303
QC Data: View QC data: current batch of CoA, Lot#CRB50303
Safety Data Sheet (MSDS): View Material Safety Data Sheet (MSDS)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490
Additional Information
References
1: Ou DL, Shen YC, Yu SL, Chen KF, Yeh PY, Fan HH, Feng WC, Wang CT, Lin LI, Hsu C, Cheng AL. Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells. Cancer Res. 2010 Nov 15;70(22):9309-18. Epub 2010 Nov 9. PubMed PMID: 21062976.
2: Burgess S, Echeverria V. Raf inhibitors as therapeutic agents against neurodegenerative diseases. CNS Neurol Disord Drug Targets. 2010 Mar;9(1):120-7. Review. PubMed PMID: 20201822.
3: Deming D, Geiger P, Chen H, Kunnimalaiyaan M, Holen K. ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. J Surg Res. 2010 Jun 1;161(1):28-32. Epub 2009 Jul 12. PubMed PMID: 20031160; PubMed Central PMCID: PMC3379885.
4: Blechacz BR, Smoot RL, Bronk SF, Werneburg NW, Sirica AE, Gores GJ. Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2. Hepatology. 2009 Dec;50(6):1861-70. PubMed PMID: 19821497; PubMed Central PMCID: PMC2891152.
5: Echeverria V, Burgess S, Gamble-George J, Arendash GW, Citron BA. Raf inhibition protects cortical cells against beta-amyloid toxicity. Neurosci Lett. 2008 Oct 17;444(1):92-6. Epub 2008 Aug 8. PubMed PMID: 18706973.
6: Deming D, Geiger P, Chen H, Vaccaro A, Kunnimalaiyaan M, Holen K. ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line. J Gastrointest Surg. 2008 May;12(5):852-7. PubMed PMID: 18299943.
7: Kunnimalaiyaan M, Ndiaye M, Chen H. Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways. Surgery. 2007 Dec;142(6):959-64; discussion 959-64. PubMed PMID: 18063082; PubMed Central PMCID: PMC2180346.
8: Houben R, Ortmann S, Schrama D, Herold MJ, Berberich I, Reichardt HM, Becker JC. Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO. J Invest Dermatol. 2007 Sep;127(9):2116-22. Epub 2007 May 3. PubMed PMID: 17476292.
9: Marzec M, Kasprzycka M, Liu X, Raghunath PN, Wlodarski P, Wasik MA. Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf. Oncogene. 2007 Feb 8;26(6):813-21. Epub 2006 Aug 7. PubMed PMID: 16909118.
10: Lai KP, Mak NK, Wei X, Wong RN, Wong MH, Wong CK. Bifunctional modulating effects of an indigo dimer (bisindigotin) to CYP1A1 induction in H4IIE cells. Toxicology. 2006 Sep 21;226(2-3):188-96. Epub 2006 Jul 4. PubMed PMID: 16901605.
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